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公开(公告)号：USRE39356E1
公开(公告)日：2006-10-17
申请号：US11056606
申请日：2005-02-11
申请人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
发明人： Wen Sen Li , John E. Thornton , Zhenrong Guo , Shankar Swaminathan , Robert M. Borzilleri , Soong-Hoon Kim , Denis Favreau
IPC分类号： C07D491/00 , C07D417/00
摘要： The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
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公开(公告)号：US06291684B1
公开(公告)日：2001-09-18
申请号：US09528230
申请日：2000-03-17
IPC分类号： C07D20326
CPC分类号： C07D491/04
摘要： The present invention relates to a stereospecific process to produce aziridinyl epothilones from oxiranyl epothilones and the intermediates derived therein.
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公开(公告)号：USRE41893E1
公开(公告)日：2010-10-26
申请号：US12539498
申请日：2009-08-11
IPC分类号： C07D417/06 , C07D277/26 , C07D277/20 , A61K31/425 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to epothilone derivatives, having the following formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
摘要翻译： 本发明涉及具有下式的埃坡霉素衍生物，其中变量G，W，Q，X，Y，B1，B2，Z1，Z2和R1-R7如本文所定义，衍生物的制备方法 及其中间体。
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公开(公告)号：US07241755B2
公开(公告)日：2007-07-10
申请号：US11512623
申请日：2006-08-30
IPC分类号： C07D493/04 , C07D417/06 , C07D227/20 , A61K31/425 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
摘要翻译： 本发明涉及下式的化合物，其中变量G，W，Q，X，Y，B 1，B 2，Z 1， Z 2，Z 2和R 1 -R 7如本文所定义，其衍生物的制备方法和中间体。
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公开(公告)号：US07125899B2
公开(公告)日：2006-10-24
申请号：US10405886
申请日：2003-04-03
IPC分类号： C07D493/04 , C07D417/06 , C07D227/20 , A61K31/425 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to epothilone derivatives, having the following formula: in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are defined herein, methods for preparation of the derivatives and intermediates thereof.
摘要翻译： 本发明涉及具有下式的埃坡霉素衍生物：其中变量G，W，Q，X，Y，B 1，B 2，Z，SUB > 1，Z 2和R 1-R 7是本文定义的衍生物及其中间体的制备方法 。
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公开(公告)号：US06605599B1
公开(公告)日：2003-08-12
申请号：US09084542
申请日：1998-05-26
IPC分类号： C07D49304
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to epothilone derivatives, having the following formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
摘要翻译： 本发明涉及埃坡霉素衍生物，其具有以下公式，其变量G，W，Q，X，Y，B1，B2，Z1，Z2和R1-R7如本文所定义，制备衍生物的方法和 其中间体。
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7.发明授权公开(公告)号：US06365749B1
公开(公告)日：2002-04-02
申请号：US09170582
申请日：1998-10-13
IPC分类号： C07D27730
CPC分类号： C07D303/38 , C07D417/06 , C07D491/04
摘要： The present invention relates to a process to produce ring opened epothilones and the novel ring opened epothilones produced thereform.
摘要翻译： 本发明涉及一种生产开环埃坡霉素的方法，以及新型开环的埃坡霉素。
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公开(公告)号：USRE41895E1
公开(公告)日：2010-10-26
申请号：US12539496
申请日：2009-08-11
IPC分类号： C07D493/04 , C07D491/04 , C07D413/04 , A61K31/4184 , A61K31/423 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to epothilone derivatives, having the following formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
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公开(公告)号：US08536327B2
公开(公告)日：2013-09-17
申请号：US11763636
申请日：2007-06-15
IPC分类号： C07D313/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to compounds of the formula where the variables are as defined in the disclosure.
摘要翻译： 本发明涉及下式的化合物，其中变量如本公开所定义。
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公开(公告)号：USRE41911E1
公开(公告)日：2010-11-02
申请号：US12539492
申请日：2009-08-11
IPC分类号： C07D498/08 , A61K31/425 , A61P35/00
CPC分类号： C07D491/044 , C07D417/06 , C07D491/04 , C07D493/04
摘要： The present invention relates to epothilone derivatives, having the following formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
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