再颁专利
USRE39464E1 Oligonucleolotides having site specific chiral phosphorothioate internucleoside linkages
有权
寡核苷酸具有位点特异性手性硫代磷酸酯核苷间键
- 专利标题： Oligonucleolotides having site specific chiral phosphorothioate internucleoside linkages
- 专利标题（中）： 寡核苷酸具有位点特异性手性硫代磷酸酯核苷间键
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申请号： US10925348申请日： 2004-08-24
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公开(公告)号： USRE39464E1公开(公告)日： 2007-01-09
- 发明人: Phillip Dan Cook , Muthiah Manoharan
- 申请人： Phillip Dan Cook , Muthiah Manoharan
- 申请人地址： US CA Carlsbad
- 专利权人： ISIS Pharmaceuticals Inc.
- 当前专利权人： ISIS Pharmaceuticals Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： ISIS Patent Department Woodcock Washburn LLP
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; G01N33/53
摘要：
Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the 3′-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.
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