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    Composition and methods for the pulmonary delivery of nucleic acids
    1.
    发明授权
    Composition and methods for the pulmonary delivery of nucleic acids 有权
    用于肺部递送核酸的组合物和方法

    公开(公告)号：US08153602B1

    公开(公告)日：2012-04-10

    申请号：US09315292

    申请日：1999-05-20

    申请人： Clarence Frank Bennett ,  David J. Ecker ,  Phillip Dan Cook

    发明人： Clarence Frank Bennett ,  David J. Ecker ,  Phillip Dan Cook

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C07H21/02

    CPC分类号： A61K48/0075

    摘要： The present invention relates to compositions and methods for the pulmonary delivery of nucleic acids, particularly oligonucleotides. In one preferred embodiment, the compositions and methods of the invention are utilized to effect the pulmonary delivery of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic or prophylactic purposes.

    摘要翻译： 本发明涉及用于肺部递送核酸，特别是寡核苷酸的组合物和方法。 在一个优选的实施方案中，本发明的组合物和方法用于将动物的反义寡核苷酸肺部递送至动物，以调节动物中基因的表达用于调查，治疗或预防目的。

    Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
    6.
    发明授权
    Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase 失效
    核苷衍生物作为RNA依赖性RNA病毒聚合酶的抑制剂

    公开(公告)号：US07323449B2

    公开(公告)日：2008-01-29

    申请号：US10520925

    申请日：2003-07-18

    申请人： David B. Olsen ,  Balkrishen Bhat ,  Phillip Dan Cook

    发明人： David B. Olsen ,  Balkrishen Bhat ,  Phillip Dan Cook

    IPC分类号： C07D487/04 ,  A61K31/52 ,  A61K31/675 ,  C07F9/6561 ,  A61P31/14

    CPC分类号： A61K45/06 ,  C07H19/14

    摘要： The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such thionucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the thionucleoside compounds of the present invention.

    摘要翻译： 本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷类化合物及其某些衍生物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。 本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合含有这样的硫代核苷化合物的药物组合物。 还公开了用本发明的硫代核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。