发明申请
- 专利标题: ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM
- 专利标题(中): 邻苯二甲酰胺和联苯胺衍生物和含有它们的抗高血压药物
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申请号: PCT/EP1991000911申请日: 1991-05-15
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公开(公告)号: WO1992000273A1公开(公告)日: 1992-01-09
- 发明人: THE BOOTS COMPANY PLC , GOPALAN, Balasubramanian
- 申请人: THE BOOTS COMPANY PLC
- 专利权人: THE BOOTS COMPANY PLC
- 当前专利权人: THE BOOTS COMPANY PLC
- 优先权: GB9014456.9 19900628
- 主分类号: C07C279/18
- IPC分类号: C07C279/18
摘要:
Compounds of formula (I) and their salts in which R1 is optionally substituted phenyl, R2 is alkyl, cycloalkyl or optionally substituted amino, or R2 and R3 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring and R5 is H, halo, alkyl, alkoxy, trifluoromethyl or a group of formula S(O)mR8 in which m is 0, 1 or 2 and R8 is alkyl have utility in the treatment of diabetes particularly in the treatment of hyperglycaemia.