发明申请
WO1993001159A1 FUSED TRICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY
审中-公开
熔化三氯化合物，含有它们的药物组合物及其在治疗中的使用
- 专利标题： FUSED TRICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY
- 专利标题（中）： 熔化三氯化合物，含有它们的药物组合物及其在治疗中的使用
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申请号： PCT/GB1992001212申请日： 1992-07-03
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公开(公告)号： WO1993001159A1公开(公告)日： 1993-01-21
- 发明人: MERCK SHARP & DOHME LIMITED
- 申请人： MERCK SHARP & DOHME LIMITED , SAARI, Walfred, Spencer , VAN NIEL, Monique, Bodil , WILLIAMS, Brian, John
- 专利权人： MERCK SHARP & DOHME LIMITED,SAARI, Walfred, Spencer,VAN NIEL, Monique, Bodil,WILLIAMS, Brian, John
- 当前专利权人： MERCK SHARP & DOHME LIMITED,SAARI, Walfred, Spencer,VAN NIEL, Monique, Bodil,WILLIAMS, Brian, John
- 优先权： GB9114886.6 19910710; GB9208141.3 19920414
- 主分类号： C07C217/48
- IPC分类号： C07C217/48
摘要：
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents a group (a) where W represents a bond, O, S, -CH2CH2-, -CH=CH- or NR ; and one or both of the phenyl rings may be replaced by a heteroaryl moiety; X and Y each represent H or X and Y together are =O; Z represents O, S or NR ; R and R independently represent H; optionally substituted C1-6 alkyl, optionally substituted phenyl(C0-4alkyl), C2-6 alkylene; COC1-6alkylhalo; COR ; COOR ; CONHR ; COC1-4alkylNR R ; or CONR C1-4alkylCONR R ; R represents H or C1-6alkyl; R represents H, C1-6 alkyl or phenyl; R represents optionally substituted (CH2)qphenyl; are tachykinin antagonists, useful for treating pain.
