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    AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS
    6.
    发明申请
    AN ISOLATED ATOMOXETINE IMPURITY, PROCESSES FOR THE PREPARATION OF ATOMOXETINE IMPURITIES AND THEIR USE AS REFERENCE STANDARDS 审中-公开
    分离的原子氧杂质杂质，原子氧杂质制备过程及其作为参考标准的用途

    公开(公告)号：WO2006004979A2

    公开(公告)日：2006-01-12

    申请号：PCT/US2005/023423

    申请日：2005-06-28

    申请人： TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L. ,  TEVA PHARMACEUTICALS USA, INC. ,  CASTELLI, Eugenio ,  VAILATI, Alessandra

    发明人： CASTELLI, Eugenio ,  VAILATI, Alessandra

    IPC分类号： C07C217/48

    CPC分类号： C07C217/16 ,  C07B2200/07 ,  C07C213/06 ,  C07C213/08 ,  C07C217/48

    摘要： The present invention provides isolated N-methyl-3-(3-methylphenoxy)-3-phenylpropylamine hydrochloride, and preparation thereof as well as of N-methyl-3-(4-methylphenoxy)-3-phenylpropylamine hydrochloride and of N-methyl-3-phenoxy-3-phenylpropylamine hydrochloride. The invention further provides the use of the above compounds as reference markers and/or reference standards during the synthesis of Atomoxetine. Also provided is a method of limiting the amounts of the impurities 3FT (3-fluorotoluene), 4FT (4-fluorotoluene), and FB (fluorobenzene) in the 2-fluorotoluene starting material used in the synthesis of Atomoxetine Hydrochloride. The purity of the Atomoxetine Hydrochloride product is ensured by determining the amounts of 3FT, 4FT, and FB in the 2-fluorotoluene starting material with the marker 3-ATM HC1.

    摘要翻译： 本发明提供分离的N-甲基-3-（3-甲基苯氧基）-3-苯基丙胺盐酸盐及其制备方法以及N-甲基-3-（4-甲基苯氧基）-3 - 苯基丙胺盐酸盐和N-甲基-3-苯氧基-3-苯基丙胺盐酸盐。 本发明进一步提供了在合成阿托莫西汀期间上述化合物作为参考标记和/或参考标准物的用途。 还提供了限制用于合成阿托莫西汀盐酸盐的2-氟甲苯原料中的杂质3FT（3-氟甲苯），4FT（4-氟甲苯）和FB（氟苯）的量的方法。 盐酸阿托莫西汀产品的纯度通过使用标记3-ATM HCl确定2-氟甲苯原料中3FT，4FT和FB的量来确保。

    FUNGICIDAL COMPOUNDS HAVING A FLUOROVINYL- OR FLUOROPROPENYL-OXYPHENYLOXIME MOIETY AND PROCESS FOR THE PREPARATION THEREOF
    9.
    发明申请
    FUNGICIDAL COMPOUNDS HAVING A FLUOROVINYL- OR FLUOROPROPENYL-OXYPHENYLOXIME MOIETY AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
    具有氟代 - 或氟代戊烯 - 氧化烯环糊精的杀真菌化合物及其制备方法

    公开(公告)号：WO01012585A1

    公开(公告)日：2001-02-22

    申请号：PCT/KR2000/000906

    申请日：2000-08-16

    IPC分类号： A01N37/36 ,  A01N37/38 ,  A01N37/50 ,  C07C251/60 ,  C07D317/54 ,  C07C229/20 ,  C07C217/48

    CPC分类号： A01N37/38 ,  A01N37/50 ,  C07C251/60 ,  C07D317/54

    摘要： A fungicidal compound of formula (I) having a fluorovinye- or fluoropropenyl-oxyphenyloxime moiety and stereoisomers thereof are useful for protecting crops from fungal diseases: wherein, X is CH or N; Y is O or NH; R is hydrogen, C1-4 alkyl, or halogen-substituted C1-4 alkyl, R is a phenyl group optionally carrying one or more substituents selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, methylenedioxy and halogen; or a naphthyl group; and R is hydrogen or CF3.

    摘要翻译： 具有氟乙烯基或氟丙烯基 - 氧基苯基肟部分的式（I）杀真菌化合物及其立体异构体可用于保护作物免受真菌疾病的影响：其中，X为CH或N; Y是O或NH; R 1是氢，C 1-4烷基或卤素取代的C 1-4烷基，R 2是任选携带一个或多个选自C 1-4烷基，C 1-4烷氧基的取代基的苯基 ，亚甲二氧基和卤素; 或萘基; R 3是氢或CF 3。