Invention Application
WO9426723A3 PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE
审中-公开
N-氰基亚氨基二碳酸酯和3-巯基-5-氨基-1H-1,2,4-三唑的制备
- Patent Title: PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE
- Patent Title (中): N-氰基亚氨基二碳酸酯和3-巯基-5-氨基-1H-1,2,4-三唑的制备
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Application No.: PCT/US9405157Application Date: 1994-05-10
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Publication No.: WO9426723A3Publication Date: 1995-02-02
- Inventor: MARSTERS JAMES C JR , BROWN MICHAEL S , CROWLEY CRAIG W , GOLDSTEIN JOSEPH L , JAMES GUY L , MCDOWELL ROBERT S , OARE DAVID , RAWSON THOMAS E , REYNOLDS MARK , SOMERS TODD G
- Applicant: GENENTECH INC , UNIV TEXAS , MARSTERS JAMES C JR , BROWN MICHAEL S , CROWLEY CRAIG W , GOLDSTEIN JOSEPH L , JAMES GUY L , MCDOWELL ROBERT S , OARE DAVID , RAWSON THOMAS E , REYNOLDS MARK , SOMERS TODD G
- Assignee: GENENTECH INC,UNIV TEXAS,MARSTERS JAMES C JR,BROWN MICHAEL S,CROWLEY CRAIG W,GOLDSTEIN JOSEPH L,JAMES GUY L,MCDOWELL ROBERT S,OARE DAVID,RAWSON THOMAS E,REYNOLDS MARK,SOMERS TODD G
- Current Assignee: GENENTECH INC,UNIV TEXAS,MARSTERS JAMES C JR,BROWN MICHAEL S,CROWLEY CRAIG W,GOLDSTEIN JOSEPH L,JAMES GUY L,MCDOWELL ROBERT S,OARE DAVID,RAWSON THOMAS E,REYNOLDS MARK,SOMERS TODD G
- Priority: US6196193 1993-05-14; US8220293 1993-06-24
- Main IPC: A61K31/55
- IPC: A61K31/55 ; A61K31/551 ; A61K38/00 ; A61P31/04 ; A61P35/00 ; C07D223/16 ; C07D243/10 ; C07D243/14 ; C07D243/24 ; C07D401/06 ; C07D401/14 ; C07D403/04 ; C07D403/06 ; C07D403/10 ; C07D403/12 ; C07D403/14 ; C07D405/06 ; C07D409/06 ; C07D409/14 ; C07D417/12 ; C07D417/14 ; C07D487/04 ; C07D498/04 ; C07D513/04 ; C07K5/02 ; C07K5/06 ; C07K5/078 ; C07K5/08 ; C07K5/083 ; C07K5/097 ; C07K5/10 ; C07K5/103 ; C07K5/117
Abstract:
Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated.
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