公开(公告)号：WO2023090366A1

公开(公告)日：2023-05-25

申请号：PCT/JP2022/042585

申请日：2022-11-16

申请人： 株式会社　ＰＲＩＳＭ　ＢｉｏＬａｂ ,  学校法人自治医科大学

发明人： 永井　良三 ,  仲矢　丈雄 ,  相澤　健一 ,  小路　弘行 ,  河西　政次 ,  中野　洋文

IPC分类号： A61K45/00 ,  A61K31/5395 ,  A61P9/00 ,  A61P9/04 ,  A61P35/00 ,  A61P43/00 ,  C07D498/04 ,  G01N33/15 ,  G01N33/50

摘要： 本発明は、新規な作用機序を有する抗がん剤及び／又は心機能改善剤の提供を課題とする。Kruppel-like factor 5（ＫＬＦ５）とUbiquitin-specific peptidase 3（ＵＳＰ３）との結合を阻害する物質、特に下記式（Ｉ）～（ＩＩＩ）： で表される化合物又はその医薬上許容され得る塩を有効成分として含む医薬組成物は、抗がん剤及び／又は心機能改善剤として有用である。

公开(公告)号：WO2023079294A1

公开(公告)日：2023-05-11

申请号：PCT/GB2022/052781

申请日：2022-11-04

申请人： SITRYX THERAPEUTICS LIMITED

发明人： COUSIN, David ,  BARBA, Oscar

IPC分类号： C07D237/30 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  A61K31/502 ,  A61P3/00 ,  A61P7/00 ,  A61P37/00 ,  A61P35/00

摘要： The invention relates to compounds of formula (Ia) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: wherein RA, RB, RC and RD, X, Y1, Y2, Y3, Z1, Z2 and m are as defined herein.

公开(公告)号：WO2023057429A1

公开(公告)日：2023-04-13

申请号：PCT/EP2022/077533

申请日：2022-10-04

申请人： ASTRAZENECA AB

发明人： POLLA, Magnus ,  BERGMAN, Joakim ,  SUNDELL, Johan ,  BRÅNALT, Jonas ,  RATKOVA, Ekaterina ,  KAJANUS, Johan ,  JOHANSSON, Magnus

IPC分类号： A61P3/00 ,  A61P9/00 ,  C07D401/14 ,  C07D405/14 ,  C07D498/04 ,  A61K31/498

摘要： There are disclosed certain 2,5-diazabicyclo[4.2.0]octanes of formula (I) and octahydrofuro[3,4-b]pyrazines, and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are GLP-1 receptor modulators and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disease and metabolic conditions, for example Type 2 diabetes.

公开(公告)号：WO2023041756A1

公开(公告)日：2023-03-23

申请号：PCT/EP2022/075878

申请日：2022-09-19

申请人： F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

发明人： ANDREOTTI, Daniele ,  CUMMING, John G. ,  FOSSATI, Giacomo ,  SAMPAOLESI, Susanna ,  SERRA, Elena

IPC分类号： C07D413/04 ,  C07D413/14 ,  C07D498/04 ,  C07D513/04 ,  A61P31/04

摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3a, R3b, R4, A1, A2, A3, A4, A5, A6, B1, B2, B3, B4, and L are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：WO2023018955A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/040191

申请日：2022-08-12

申请人： ELI LILLY AND COMPANY

发明人： COATES, David Andrew ,  CAO, Yizheng

IPC分类号： A61P35/00 ,  C07D498/04 ,  A61K31/5365 ,  C07C65/05

摘要： Solid forms including 7-[[(1S)-1-[4-[(1S)-2-cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one and a dihydroxybenzoic acid selected from 2,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid are provided, as well as pharmaceutical compositions including the solid forms, methods for using the solid forms in treating cancer patients, and methods of making the solid forms.

公开(公告)号：WO2023012711A1

公开(公告)日：2023-02-09

申请号：PCT/IB2022/057237

申请日：2022-08-04

申请人： 주식회사 엘지화학

发明人： 김민준 ,  김영석 ,  이동훈 ,  서상덕 ,  김우한

IPC分类号： C07D498/04 ,  C07D513/04 ,  H01L51/00 ,  H01L51/50

摘要： 본 발명은 신규한 화합물 및 이를 포함하는 유기 발광 소자를 제공한다.

公开(公告)号：WO2023006893A1

公开(公告)日：2023-02-02

申请号：PCT/EP2022/071231

申请日：2022-07-28

申请人： CONFO THERAPEUTICS N.V.

发明人： DE BLIECK, Ann ,  MENET, Christel Jeanne Marie

IPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  A61P29/00 ,  A61K31/496 ,  A61K31/497 ,  A61K31/517 ,  A61K31/551

摘要： The present invention relates to compounds that can be used for the prevention, treatment and/or management of pain, in particular chronic pain, such as neuropathic pain, and/or other diseases or disorders that are associated with AT2R and/or AT2R-mediated signaling.

公开(公告)号：WO2023004257A1

公开(公告)日：2023-01-26

申请号：PCT/US2022/073756

申请日：2022-07-15

申请人： GENENTECH, INC.

发明人： LAI, Kwong Wah ,  NILEWSKI, Christian ,  PASTOR, Richard M. ,  STIVALA, Craig

IPC分类号： C07D498/04 ,  A61P1/00 ,  A61P1/16 ,  A61P5/00 ,  A61P9/00 ,  A61P11/00 ,  A61P17/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61K31/4188

摘要： Described herein are sulfonimidamide compounds, solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing. Further described herein are methods of treating a disorder in a subject in need thereof using said compounds, solvates, tautomers, or pharmaceutically acceptable salts thereof, such as NLRP3-mediated disorders.

公开(公告)号：WO2023283256A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/036242

申请日：2022-07-06

申请人： ALIGOS THERAPEUTICS, INC. ,  KATHOLIEKE UNIVERSITEIT LEUVEN

发明人： VANDYCK, Koen ,  BARDIOT, Dorothée Alice Marie-Eve ,  RABOISSON, Pierre Jean-Marie Bernard ,  BEIGELMAN, Leonid ,  STOYCHEVA, Antitsa Dimitrova ,  BOLAND, Sandro ,  MARCHAND, Arnaud Didier Marie

IPC分类号： A61P31/14 ,  A61P31/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07D491/048 ,  C07D491/20 ,  C07D498/04 ,  A61K31/403 ,  A61K31/4162 ,  A61K31/4192 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383

摘要： Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：WO2023279105A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/073385

申请日：2022-07-01

申请人： AERIE PHARMACEUTICALS, INC.

发明人： ELLIS, David Archer ,  GORDHAN, Heeren M. ,  LICHOROWIC, Cynthia L. ,  STURDIVANT, Jill M. ,  DELONG, Mitchell A. ,  KOPCZYNSKI, Casey ,  WHITE, Jeffrey C. ,  SENCHYNA, Michelle ,  HOLLANDER, David

IPC分类号： A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D491/06 ,  C07D498/04 ,  A61K31/506 ,  A61K31/5377

摘要： Provided herein are azetidine pyrimidine compounds. In particular, provided herein are compounds that affect the function of kinases in a cell, and that are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including inflammatory eye diseases such as uveitis, cardiovascular diseases, inflammatory diseases, and diseases characterized by abnormal growth, such as cancers. Also provided herein are compositions comprising azetidine pyrimidine compounds.