Invention Application
- Patent Title: METHODS FOR TREATING RESISTANT TUMORS
- Patent Title (中): 治疗抵抗性肿瘤的方法
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Application No.: PCT/US1996017533Application Date: 1996-11-04
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Publication No.: WO1997017069A1Publication Date: 1997-05-15
- Inventor: ELI LILLY AND COMPANY
- Applicant: ELI LILLY AND COMPANY , DANTZIG, Anne, H. , GRESE, Timothy, A. , NORMAN, Bryan, H. , PALKOWITZ, Alan, D. , SLUKA, James, P. , STARLING, James, J., II , WINTER, Mark, A.
- Assignee: ELI LILLY AND COMPANY,DANTZIG, Anne, H.,GRESE, Timothy, A.,NORMAN, Bryan, H.,PALKOWITZ, Alan, D.,SLUKA, James, P.,STARLING, James, J., II,WINTER, Mark, A.
- Current Assignee: ELI LILLY AND COMPANY,DANTZIG, Anne, H.,GRESE, Timothy, A.,NORMAN, Bryan, H.,PALKOWITZ, Alan, D.,SLUKA, James, P.,STARLING, James, J., II,WINTER, Mark, A.
- Priority: US60/006,350 19951107
- Main IPC: A61K31/38
- IPC: A61K31/38
Abstract:
This invention provides a series of substituted benzo[b]thiophenes useful in reversing multidrug resistance in a resistant neoplasm. The present invention also provides methods for reversing the multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted benzothiophene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted benzothiophene in combination with an oncolytic agent.
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