公开(公告)号：WO1997017069A1

公开(公告)日：1997-05-15

申请号：PCT/US1996017533

申请日：1996-11-04

Applicant: ELI LILLY AND COMPANY ,  DANTZIG, Anne, H. ,  GRESE, Timothy, A. ,  NORMAN, Bryan, H. ,  PALKOWITZ, Alan, D. ,  SLUKA, James, P. ,  STARLING, James, J., II ,  WINTER, Mark, A.

Inventor： ELI LILLY AND COMPANY

IPC: A61K31/38

CPC classification number: C07D333/56 ,  A61K31/4535

Abstract: This invention provides a series of substituted benzo[b]thiophenes useful in reversing multidrug resistance in a resistant neoplasm. The present invention also provides methods for reversing the multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted benzothiophene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted benzothiophene in combination with an oncolytic agent.

Abstract translation: 本发明提供一系列用于逆转耐药性肿瘤中多药耐药性的取代的苯并[b]噻吩。 本发明还提供了通过用取代的苯并噻吩处理需要所述治疗的哺乳动物来逆转耐药性肿瘤中的多药耐药性的方法。 本发明还提供了用于治疗哺乳动物肿瘤的方法，其包括向需要这种治疗的哺乳动物施用取代的苯并噻吩与溶瘤剂组合。