发明申请
- 专利标题： CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO
- 专利标题（中）： CRF受体拮抗剂及其相关方法
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申请号： PCT/US9927054申请日： 1999-11-12
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公开(公告)号： WO0027846A3公开(公告)日： 2000-11-16
- 发明人: HADDACH MUSTAPHA , NELSON JODIE , DYCK BRIAN P , GUO ZHIQIANG , HUANG CHARLES Q , MCCARTHY JAMES R
- 申请人： NEUROCRINE BIOSCIENCES INC , HADDACH MUSTAPHA , NELSON JODIE , DYCK BRIAN P , GUO ZHIQIANG , HUANG CHARLES Q , MCCARTHY JAMES R
- 专利权人： NEUROCRINE BIOSCIENCES INC,HADDACH MUSTAPHA,NELSON JODIE,DYCK BRIAN P,GUO ZHIQIANG,HUANG CHARLES Q,MCCARTHY JAMES R
- 当前专利权人： NEUROCRINE BIOSCIENCES INC,HADDACH MUSTAPHA,NELSON JODIE,DYCK BRIAN P,GUO ZHIQIANG,HUANG CHARLES Q,MCCARTHY JAMES R
- 优先权： US19107398 1998-11-12; US37083799 1999-08-09; US40136499 1999-09-21
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; A61K31/551 ; A61P5/02 ; A61P25/00 ; A61P25/08 ; A61P25/18 ; A61P25/24 ; C07D471/16 ; C07D487/16
摘要：
CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have structure (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein n , m , A, B, C, R, R1, R2 and Ar are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.
IPC分类:
