Invention Application
WO0127135A9 REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO
审中-公开
HEDGEHOG路径的调节器，组件和与之相关的用途
- Patent Title: REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO
- Patent Title (中): HEDGEHOG路径的调节器，组件和与之相关的用途
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Application No.: PCT/US0028479Application Date: 2000-10-13
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Publication No.: WO0127135A9Publication Date: 2002-08-15
- Inventor: BEACHY PHILIP A
- Applicant: UNIV JOHNS HOPKINS MED
- Assignee: UNIV JOHNS HOPKINS MED
- Current Assignee: UNIV JOHNS HOPKINS MED
- Priority: US15921599 1999-10-13; US22927300 2000-08-30
- Main IPC: A61K31/58
- IPC: A61K31/58 ; A61P1/02 ; A61P1/16 ; A61P1/18 ; A61P11/00 ; A61P15/16 ; A61P15/18 ; A61P17/00 ; A61P17/02 ; A61P17/04 ; A61P17/06 ; A61P17/08 ; A61P17/12 ; A61P17/14 ; A61P17/16 ; A61P19/02 ; A61P19/04 ; A61P19/08 ; A61P25/00 ; A61P25/02 ; A61P25/14 ; A61P25/16 ; A61P25/28 ; A61P27/00 ; A61P27/12 ; A61P35/00 ; A61P43/00 ; C07J69/00
Abstract:
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
Public/Granted literature
- WO0127135A2 REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO Public/Granted day:2001-04-19
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