Invention Application
- Patent Title: METHODS
- Patent Title (中): 方法
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Application No.: PCT/GB0202294Application Date: 2002-05-15
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Publication No.: WO02095069A3Publication Date: 2003-10-16
- Inventor: MOORE RACHAEL
- Applicant: ASTRAZENECA AB , ASTRAZENECA UK LTD , MOORE RACHAEL
- Assignee: ASTRAZENECA AB,ASTRAZENECA UK LTD,MOORE RACHAEL
- Current Assignee: ASTRAZENECA AB,ASTRAZENECA UK LTD,MOORE RACHAEL
- Priority: GB0112256 2001-05-18; US29292601 2001-05-24
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/48
Abstract:
The invention provides a method for the detection of a polymorphism in OATPB in a human which method comprises determining the sequence of the human at one of the following positions: position (1113) of SEQ ID NO: 4 and/or position (312) of SEQ ID NO: 5. The polymorphism at position (1113) is presence of G and/or A and the polymorphism at position (312) is presence of Arg and/or Gln. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of a drug transportable by OATB.
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