公开(公告)号：WO2002095069A2

公开(公告)日：2002-11-28

申请号：PCT/GB2002/002294

申请日：2002-05-15

Applicant: ASTRAZENECA AB ,  ASTRAZENECA UK LIMITED ,  MOORE, Rachael

Inventor： MOORE, Rachael

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: The invention provides a method for the detection of a polymorphism in OATPB in a human which method comprises determining the sequence of the human at one of the following positions: position (1113) of SEQ ID NO: 4 and/or position (312) of SEQ ID NO: 5. The polymorphism at position (1113) is presence of G and/or A and the polymorphism at position (312) is presence of Arg and/or Gln. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of a drug transportable by OATB.

Abstract translation: 本发明提供了一种用于检测人中OATPB多态性的方法，该方法包括在以下位置之一确定人的序列：SEQ ID NO：4的位置（1113）和/或SEQ ID NO：4的位置（312） SEQ ID NO：5。位置（1113）上的多态性是G和/或A的存在，位置（312）处的多态性是Arg和/或Gln的存在。 检测核酸多态性的方法选自扩增耐火突变体系和限制性片段长度多态性。 本发明还提供了评估OATB可运输药物的药物遗传学的方法的用途。

公开(公告)号：WO2003106708A1

公开(公告)日：2003-12-24

申请号：PCT/GB2003/002487

申请日：2003-06-10

Applicant: ASTRAZENECA AB ,  ASTRAZENECA UK LIMITED ,  MOORE, Rachael

Inventor： MOORE, Rachael

IPC: C12Q1/68

CPC classification number: C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The invention provides a method for the detection of a polymorphism in OATPF in a human. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of a drug transportable by OATF.

Abstract translation: 本发明提供了检测人中OATPF中的多态性的方法。 检测核酸多态性的方法选自扩增耐火突变体系和限制性片段长度多态性。 本发明还提供了评估OATF可运输药物的药物遗传学的方法的用途。

公开(公告)号：WO2004073777A8

公开(公告)日：2004-09-02

申请号：PCT/AU2004/000206

申请日：2004-02-20

Applicant: RESMED LIMITED ,  GING, Anthony, Michael ,  KWOK, Philip, Rodney ,  ROBINSON, Gary, Christopher ,  MOORE, Rachael ,  SANTOSO, Bianto ,  MCAULIFFE, Patrick, John

Inventor： GING, Anthony, Michael ,  KWOK, Philip, Rodney ,  ROBINSON, Gary, Christopher ,  MOORE, Rachael ,  SANTOSO, Bianto ,  MCAULIFFE, Patrick, John

IPC: A61M16/06

Abstract: A mask system is provided to fit pre-adult patients, or patients having facial features that are very small or child-like, e.g., patients having dimensions in the lower 5%­10% of the population. For example, the headgear and/or cushion are dimensioned to accommodate this range of patients.

公开(公告)号：WO2003090827A1

公开(公告)日：2003-11-06

申请号：PCT/AU2003/000458

申请日：2003-04-17

Applicant: RESMED LIMITED ,  MOORE, Rachael ,  GING, Anthony ,  NASR, Saad ,  KWOK, Philip ,  PRICE, Andrew ,  DANTANARAYANA, Muditha

Inventor： MOORE, Rachael ,  GING, Anthony ,  NASR, Saad ,  KWOK, Philip ,  PRICE, Andrew ,  DANTANARAYANA, Muditha

IPC: A61M16/06

CPC classification number: A61M16/0816 ,  A61M16/0066 ,  A61M16/06 ,  A61M16/0616 ,  A61M16/0622 ,  A61M16/0633 ,  A61M16/0683 ,  A61M16/0694 ,  A61M16/0825 ,  A61M16/0875 ,  A61M2206/14 ,  A61M2210/0618 ,  A62B18/084 ,  Y10T24/1959 ,  Y10T24/32

Abstract: A respiratory mask (10) having a cushion (40) with a side wass structure and a seal extending away from the side wall to define a trapezoidal aperture. The side wall of the cushion is removably attached to a frame (20) of the mask and head gear (80) is also removably attached (94) and to the frame.

Abstract translation: 一种呼吸面具（10），具有具有侧壁结构的衬垫（40）和远离侧壁延伸以限定梯形孔的密封件。 衬垫的侧壁可移除地附接到面罩的框架（20），并且头部齿轮（80）也可移除地附接（94）并且连接到框架。

公开(公告)号：WO02095069A3

公开(公告)日：2003-10-16

申请号：PCT/GB0202294

申请日：2002-05-15

Applicant: ASTRAZENECA AB ,  ASTRAZENECA UK LTD ,  MOORE RACHAEL

Inventor： MOORE RACHAEL

IPC: C12Q1/68 ,  G01N33/48

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: The invention provides a method for the detection of a polymorphism in OATPB in a human which method comprises determining the sequence of the human at one of the following positions: position (1113) of SEQ ID NO: 4 and/or position (312) of SEQ ID NO: 5. The polymorphism at position (1113) is presence of G and/or A and the polymorphism at position (312) is presence of Arg and/or Gln. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of a drug transportable by OATB.

Abstract translation: 本发明提供了一种用于检测人中OATPB多态性的方法，该方法包括在以下位置之一确定人的序列：SEQ ID NO：4的位置（1113）和/或SEQ ID NO：4的位置（312） SEQ ID NO：5。位置（1113）上的多态性是G和/或A的存在，位置（312）处的多态性是Arg和/或Gln的存在。 检测核酸多态性的方法选自扩增耐火突变体系和限制性片段长度多态性。 本发明还提供了评估OATB可运输药物的药物遗传学的方法的用途。

公开(公告)号：WO2005097247A8

公开(公告)日：2005-12-01

申请号：PCT/AU2005000515

申请日：2005-04-08

Applicant: RESMED LTD ,  GUNARATNAM MICHAEL KASSIPILLAI ,  KWOK PHILIP RODNEY ,  HITCHCOCK ROBIN GARTH ,  VELISS LEE JAMES ,  GUNEY MEMDUH ,  SOKOLOV RICHARD ,  LITHGOW PERRY DAVID ,  DARKIN DONALD ,  LYNCH SUSAN ROBYN ,  DANTANARAYANA MUDITHA ,  MOORE RACHAEL

Inventor： GUNARATNAM MICHAEL KASSIPILLAI ,  KWOK PHILIP RODNEY ,  HITCHCOCK ROBIN GARTH ,  VELISS LEE JAMES ,  GUNEY MEMDUH ,  SOKOLOV RICHARD ,  LITHGOW PERRY DAVID ,  DARKIN DONALD ,  LYNCH SUSAN ROBYN ,  DANTANARAYANA MUDITHA ,  MOORE RACHAEL

IPC: A61M15/08 ,  A61M16/06 ,  A61M16/08 ,  A62B7/00

CPC classification number: A61M16/0666 ,  A61M16/0066 ,  A61M16/06 ,  A61M16/0611 ,  A61M16/0683 ,  A61M16/0825 ,  A61M2210/0618

Abstract: A nasal assembly (600) for delivering breathable gas to a patient includes a frame (616) having an integrally formed first connector portion (618). A nozzle assembly (604) includes a gusset or base portion and a pair of nozzles. At least one inlet conduit (606) is structured to deliver breathable gas into the frame (616) and nozzle assembly (604) for breathing by the patient. A pair of second connector portions (20, 40, 614, 622, 636) are removably and rotatably connected to respective first connector portions (618) of the frame (616) and are in communication with respective inlet conduits (606), e.g., directly or via angle connectors (612). A headgear assembly (602) is removably connected to the pair of second connector portions (20, 40, 614, 622, 636) and/or the angle connectors (612) so as to maintain the frame (616) and the nozzle assembly (604) in a desired adjusted position on the patient's face.

Abstract translation: 用于向患者输送可呼吸气体的鼻部组件（600）包括具有整体形成的第一连接器部分（618）的框架（616）。 喷嘴组件（604）包括角撑板或基座部分和一对喷嘴。 至少一个入口导管（606）被构造成将可呼吸气体输送到框架（616）和喷嘴组件（604）中以供患者呼吸。 一对第二连接器部分（20,40,614,622,636）可移除地且可旋转地连接到框架（616）的相应第一连接器部分（618）并且与相应的入口导管（606）连通，例如， 直接或通过角连接器（612）。 头盔组件（602）可拆卸地连接到一对第二连接器部分（20,40,614,622,636）和/或角连接器（612），以便保持框架（616）和喷嘴组件（ 604）在患者面部上的期望的调整位置上。

公开(公告)号：WO2005097247A1

公开(公告)日：2005-10-20

申请号：PCT/AU2005/000515

申请日：2005-04-08

Applicant: RESMED LIMITED ,  GUNARATNAM, Michael, Kassipillai ,  KWOK, Philip, Rodney ,  HITCHCOCK, Robin, Garth ,  VELISS, Lee, James ,  GUNEY, Memduh ,  SOKOLOV, Richard ,  LITHGOW, Perry, David ,  DARKIN, Donald ,  LYNCH, Susan, Robyn ,  DANTANARAYANA, Muditha ,  MOORE, Rachael

Inventor： GUNARATNAM, Michael, Kassipillai ,  KWOK, Philip, Rodney ,  HITCHCOCK, Robin, Garth ,  VELISS, Lee, James ,  GUNEY, Memduh ,  SOKOLOV, Richard ,  LITHGOW, Perry, David ,  DARKIN, Donald ,  LYNCH, Susan, Robyn ,  DANTANARAYANA, Muditha ,  MOORE, Rachael

IPC: A61M16/06

CPC classification number: A61M16/0066 ,  A61M16/06 ,  A61M16/0611 ,  A61M16/0666 ,  A61M16/0683 ,  A61M16/0825 ,  A61M2210/0618

Abstract: A nasal assembly (600) for delivering breathable gas to a patient includes a frame (616) having an integrally formed first connector portion (618). A nozzle assembly (604) includes a gusset or base portion and a pair of nozzles. At least one inlet conduit (606) is structured to deliver breathable gas into the frame (616) and nozzle assembly (604) for breathing by the patient. A pair of second connector portions (20, 40, 614, 622, 636) are removably and rotatably connected to respective first connector portions (618) of the frame (616) and are in communication with respective inlet conduits (606), e.g., directly or via angle connectors (612). A headgear assembly (602) is removably connected to the pair of second connector portions (20, 40, 614, 622, 636) and/or the angle connectors (612) so as to maintain the frame (616) and the nozzle assembly (604) in a desired adjusted position on the patient's face.

Abstract translation: 用于将可呼吸气体输送到患者的鼻部组件（600）包括具有整体形成的第一连接器部分（618）的框架（616）。 喷嘴组件（604）包括角撑板或基部部分和一对喷嘴。 至少一个入口管道（606）被构造成将可透气的气体输送到框架（616）和喷嘴组件（604）中，以便患者呼吸。 一对第二连接器部分（20,40,614,622,636）可移除地和可旋转地连接到框架（616）的相应的第一连接器部分（618）并且与相应的入口导管（606）连通，例如， 直接或通过角度连接器（612）。 一种头带组件（602）可移除地连接到一对第二连接器部分（20,40,614,622,636）和/或角度连接器（612），以便保持框架（616）和喷嘴组件（ 604）在患者脸部上的期望的调整位置。

公开(公告)号：WO2004073777A1

公开(公告)日：2004-09-02

申请号：PCT/AU2004000206

申请日：2004-02-20

Applicant: RESMED LTD ,  GING ANTHONY MICHAEL ,  KWOK PHILIP RODNEY ,  ROBINSON GARY CHRISTOPHER ,  MOORE RACHAEL ,  SANTOSO BIANTO ,  MCAULIFFE PATRICK JOHN

Inventor： GING ANTHONY MICHAEL ,  KWOK PHILIP RODNEY ,  ROBINSON GARY CHRISTOPHER ,  MOORE RACHAEL ,  SANTOSO BIANTO ,  MCAULIFFE PATRICK JOHN

IPC: A61M16/00 ,  A61M16/06

CPC classification number: A61M16/0683 ,  A61M16/06 ,  A61M16/0616 ,  A61M16/0622 ,  A61M2210/0618

Abstract: A mask system is provided to fit pre-adult patients, or patients having facial features that are very small or child-like, e.g., patients having dimensions in the lower 5%­10% of the population. For example, the headgear and/or cushion are dimensioned to accommodate this range of patients.

Abstract translation: 提供掩模系统以适合成年前患者，或具有非常小或儿童样的面部特征的患者，例如具有在人群的5％10％以下的维度的患者。 例如，头带和/或衬垫的尺寸适于容纳该范围的患者。