发明申请
WO2004013119B1 THE 9, 11-CYCLOENDOPEROXIDE PRO-DRUGS OF PROSTAGLANDIN ANALOGUES FOR TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA
审中-公开
前列环素类似物9,11-环十二烷氧基前药用于治疗高眼压和青光眼
- 专利标题： THE 9, 11-CYCLOENDOPEROXIDE PRO-DRUGS OF PROSTAGLANDIN ANALOGUES FOR TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA
- 专利标题（中）： 前列环素类似物9,11-环十二烷氧基前药用于治疗高眼压和青光眼
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申请号： PCT/US0324305申请日： 2003-08-04
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公开(公告)号： WO2004013119B1公开(公告)日： 2004-05-06
- 发明人: LING KAH-HIING JOHN , YANG WU , NI JINSONG , YUAN HAIQING , TANG-LIU DIANE D S
- 申请人： ALLERGAN INC
- 专利权人： ALLERGAN INC
- 当前专利权人： ALLERGAN INC
- 优先权： US21243702 2002-08-05
- 主分类号： A61K31/357
- IPC分类号： A61K31/357 ; A61P1/04 ; A61P7/02 ; A61P9/12 ; A61P27/00 ; A61P27/02 ; A61P27/06 ; A61P29/00 ; A61P43/00 ; C07D317/06
摘要：
9,11-Cycloendoperoxide derivatives of biologically active prostaglandin analogs, and particularly of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin H2 1-ethanolamide or of structurally closely related analogs, are pro-drugs which hydrolyze under physiological conditions to provide prostaglandin analogues that are capable of providing sustained ocular and other in vivo concentrations of the respective drugs. The compounds of the invention have the formula shown below where the variables have the meaning defined in the specification.
