Invention Application
- Patent Title: STABILIZED PHARMACEUTICAL COMPOSITIONS OF SAFINGOL AND METHODS OF USING THE SAME
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Application No.: PCT/US2004/004960Application Date: 2004-02-19
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Publication No.: WO2004075834A3Publication Date: 2004-09-10
- Inventor: MAURER, Barry, James , REYNOLDS, Patrick, C. , VISHNUVAJJALA, Rao, B. , GUPTA, Shanker
- Applicant: CHILDRENS HOSPITAL LOS ANGELES RESEARCH INSTITUTE , MAURER, Barry, James , REYNOLDS, Patrick, C. , VISHNUVAJJALA, Rao, B. , GUPTA, Shanker
- Applicant Address: 4650 Sunset Boulevard, Los Angeles, CA 90027 US
- Assignee: CHILDRENS HOSPITAL LOS ANGELES RESEARCH INSTITUTE,MAURER, Barry, James,REYNOLDS, Patrick, C.,VISHNUVAJJALA, Rao, B.,GUPTA, Shanker
- Current Assignee: CHILDRENS HOSPITAL LOS ANGELES RESEARCH INSTITUTE,MAURER, Barry, James,REYNOLDS, Patrick, C.,VISHNUVAJJALA, Rao, B.,GUPTA, Shanker
- Current Assignee Address: 4650 Sunset Boulevard, Los Angeles, CA 90027 US
- Agency: MYERS BIGEL SIBLEY & SAJOVEC, P.A.
- Priority: US60/449,536 20030221
- Main IPC: A61K31/133
- IPC: A61K31/133
Abstract:
The present invention provides stable aqueous solutions consisting essentially of: (a) a sphingolipid; (b) lactic acid; and (c) optionally a stabilizing agent; wherein the solution has a molar ratio of lactic acid to sphingolipid of 1:1 to 10:1. The present invention further provides an emulsion formulation consisting essentially of: (a) lactic acid; (b) a sphingolipid, wherein the sphingolipid is present in an amount of about .1 to about 30 mg/ml of emulsion; (b) optionally an isotonic agent; and (c) a phospholipid present in an amount of about 0.2 to about 200 mg/ml of emulsion. Methods of making and using the compositions are also provided.
Information query
