公开(公告)号：WO2023043876A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/043589

申请日：2022-09-15

Applicant: OCUSOFT, INC.

Inventor： ADKINS, Nat ,  SMITH, Troy ,  SARKAR, Paramita ,  SANDS, Brandon

IPC: A61K31/133 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61P17/00

Abstract: A composition for treating dry skin includes therapeutically active concentrations of one or more skin protecting lipids in an oleaginous base. The skin protecting lipids can include a sphingolipid and at least one oil. The composition is intended for application on the skin surrounding the eyes. The composition is configured to form a protective, occlusive layer that can moisturize the skin and reduce inflammation and itching without stinging, burning, or stripping the skin. According to an exemplary embodiment, the composition is formulated as a high viscosity ointment or gel.

公开(公告)号：WO2023280295A1

公开(公告)日：2023-01-12

申请号：PCT/CN2022/104551

申请日：2022-07-08

Applicant: 勤浩医药（苏州）有限公司

Inventor： 王奎锋 ,  李家鹏 ,  张涛

IPC: C07C39/14 ,  C07C13/28 ,  C07D213/02 ,  A61K31/133 ,  A61K31/40 ,  A61K31/397 ,  A61K31/44 ,  A61P5/32 ,  A61P35/00

Abstract: 一种式(Ⅰ)化合物或其药学上可接受的盐、酯、异构体、溶剂化物、前药或同位素标记物，所述式(Ⅰ)化合物的结构为：所述化合物具有很好的选择性抑制雌激素受体活性的抑制能力和对雌激素受体野生型、Y537S及D538G突变体的人乳腺癌细胞株MCF-7细胞株的抗增殖活性，所提供的化合物能够用于预防和/或治疗雌激素受体介导的或依赖性的疾病和病症。

公开(公告)号：WO2022265054A1

公开(公告)日：2022-12-22

申请号：PCT/JP2022/024020

申请日：2022-06-15

Applicant: 株式会社アジュバンホールディングス

Inventor： 高橋　秀樹 ,  中村　荘太

IPC: C07H19/167 ,  A61P17/14 ,  A61Q7/00 ,  A61K8/41 ,  A61K8/60 ,  C12N15/09 ,  A61K31/133 ,  A61K31/7076

Abstract: 頭髪、須毛、眉毛および／または睫毛などの毛における毛幹成長を促進し、毛乳頭細胞における育毛に寄与する遺伝子発現を亢進し、発毛、毛幹伸長速度の向上、毛幹最大長の向上、および毛幹径の増大する効果を奏する外用剤である育毛剤を提供するため、育毛剤の有効成分として、フィトスフィンゴシンおよびアデノシンを共に含有するもの、および／または、育毛剤の有効成分としてフィトスフィンゴシンおよびアデノシンを併用するものとする。

公开(公告)号：WO2022265052A1

公开(公告)日：2022-12-22

申请号：PCT/JP2022/024018

申请日：2022-06-15

Applicant: 株式会社アジュバンホールディングス

Inventor： 高橋　秀樹 ,  中村　荘太

IPC: A61P17/14 ,  A61Q7/00 ,  A61K8/41 ,  A61K8/64 ,  C12N15/09 ,  A61K38/06 ,  A61K31/133

Abstract: 頭髪、須毛、眉毛および／または睫毛などの毛における毛幹成長を促進し、毛乳頭細胞における育毛に寄与する遺伝子発現を亢進し、発毛、毛幹伸長速度の向上、毛幹最大長の向上、及び毛幹径の増大する効果を奏する外用剤である育毛剤を提供するため、有効成分として、パルミトイルジペプチド－５ジアミノブチロイルヒドロキシスレオニン、パルミトイルジペプチド－５ジアミノヒドロキシ酪酸、フィトスフィンゴシンを含有し、または、パルミトイルジペプチド－５ジアミノブチロイルヒドロキシスレオニンおよびパルミトイルジペプチド－５ジアミノヒドロキシ酪酸を併用するものとする。

公开(公告)号：WO2022149125A1

公开(公告)日：2022-07-14

申请号：PCT/IL2022/050003

申请日：2022-01-02

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： BARUCH LESHEM, Avigail-Elah ,  LAMPEL, Ayala ,  MASSARANO, Tlalit

IPC: A61Q1/02 ,  A61K8/02 ,  A61K8/72 ,  A61Q17/04 ,  A61Q19/04 ,  A61K31/721 ,  A61K31/25 ,  A61K31/135 ,  A61K31/133 ,  A61K31/404 ,  A61K38/43

Abstract: The invention relates to a composition comprising a polymer - based droplet, wherein the polymer - based droplet comprises one or more of melanin, a tyrosine substrate with a cleavable protecting group on the side chain, tyrosine, tyrosinase and any combination thereof. The composition further relates to a method of synthesizing melanin comprising the steps of: obtaining a polymer - based droplet containing a tyrosine substrate with a cleavable protecting group on the side chain (protected tyrosine) or a polymer - based droplet containing tyrosine (unprotected); wherein the tyrosine is oxidized by tyrosinase and polymerizes so as to obtain melanin.

公开(公告)号：WO2022133332A2

公开(公告)日：2022-06-23

申请号：PCT/US2021/064243

申请日：2021-12-17

Applicant: NALU BIO, INC.

Inventor： SAMMIS, Glenn ,  ROGGEN, Markus ,  ROBERTS, Matthew ,  KREBS, Caitlyn

IPC: C07D311/80 ,  C07C39/08 ,  C07C39/23 ,  C07C215/52 ,  A61P29/00 ,  A61K31/05 ,  A61K31/133 ,  A61K31/352 ,  C07C215/50 ,  C07C2601/16 ,  C07C303/28 ,  C07C37/055 ,  C07C37/0555 ,  C07C37/16 ,  C07C41/16 ,  C07C41/30 ,  C07C45/56 ,  C07C67/29 ,  C07C67/293

Abstract: Methods are provided for the synthesis of olivetol, olivetol analogs, cannabidiol (CBD), CBD analogs, and other cannabinoids; one method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((-)-trans-Δ 9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.

公开(公告)号：WO2022117404A1

公开(公告)日：2022-06-09

申请号：PCT/EP2021/082733

申请日：2021-11-24

Applicant: UNILEVER IP HOLDINGS B.V. ,  UNILEVER GLOBAL IP LIMITED ,  CONOPCO, INC., d/b/a UNILEVER

Inventor： ALEXANDER, Thrisha, Cleetus ,  GHOSH, Rimpa ,  MAJUMDAR, Amitabha ,  MATHAPATHI, Mruthyunjaya, Swamy ,  THIMMAIAH, Sreenivasa ,  WASKAR, Morris

IPC: A61K8/00 ,  A61K31/02 ,  A61K31/133 ,  A61K31/20 ,  A61K31/201 ,  A61K38/00 ,  A61K45/06 ,  A61P31/00 ,  A61P31/04 ,  A61K8/365 ,  A61Q17/00

Abstract: The invention relates to new use of hydroxystearic acid for inducing secretion of anti-microbial peptides (AMPs) when applied on an external surface of the human body. It also relates to an antimicrobial composition comprising a combination of hydroxystearic acid and antimicrobial peptides or antimicrobial lipids or mixtures thereof. This has application in improving the immunity of skin, scalp and oral cavity against attack by microorganisms.

公开(公告)号：WO2022015348A1

公开(公告)日：2022-01-20

申请号：PCT/US2020/052362

申请日：2020-09-24

Applicant: HARBINS RUHR BIOSCIENCE, INC.

Inventor： GULBINS, Erich

IPC: A61K31/133 ,  A61P11/00 ,  A61P31/14 ,  A61K9/00 ,  A61K31/167 ,  A61K31/4409 ,  A61K31/135 ,  A61K31/137 ,  A61K31/166 ,  A61K31/42 ,  A61K31/40 ,  A61K31/415 ,  A61K31/426 ,  A61K31/185 ,  A61K31/4245

Abstract: Provided are processes for the prevention or treatment of infection by SARS-CoV-2. Some aspects provide administration of a sphingoid compound, optionally sphingosine, an active ingredient that activates generation of a sphingoid base, optionally of sphingosine; or an active agent that inhibits the degradation of a sphingoid base, optionally of sphingosine, to a subject such as a human. By increasing the local concentration of sphingosine in a subject or an area of a subject to which the composition is administered such as the airways, nose or interior of the nose or portion thereof, the ability or SARS-CoV-2 to infect the subject or cells thereof is reduced thereby treating of preventing infection by the virus.

公开(公告)号：WO2022010054A1

公开(公告)日：2022-01-13

申请号：PCT/KR2020/019239

申请日：2020-12-28

Applicant: 솔루스바이오텍 주식회사

Inventor： 이관형 ,  김아라 ,  김상철 ,  한지혜 ,  김영범 ,  서대방

IPC: C07C233/31 ,  A61K8/68 ,  A61Q19/00 ,  A61K31/133 ,  A61P29/00

Abstract: 본 발명은 측쇄 지방산을 갖는 스핑고지질을 유효성분으로 포함하는 미세먼지 흡착을 방지하고 피부장벽기능을 향상시키고 우수한 피부 보습 효과를 가지는 피부도포용 조성물 및 이의 제조방법에 관한 것이다.

公开(公告)号：WO2021222781A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/030224

申请日：2021-04-30

Applicant: TOBIA, Annette M.

Inventor： TOBIA, Annette M.

IPC: A61K31/133 ,  A61P31/12 ,  A61P31/14 ,  A61P31/04 ,  A61P43/00 ,  A61P35/00

Abstract: A composition for, and method of, treating a condition in a subject wherein said condition is brought about, at least in part, by a cytokine storm in the subject, comprising administering to the subject said composition which comprises meglumine or a salt thereof.