Invention Application
WO2005007853A3 INHIBITION OF APOPTOSIS-SPECIFIC ELF-5A ("EIF-5A1") WITH ANTISENSE OLIGONUCLEOTIDES AND SIRNAS AS ANTI-INFLAMMATORY THERAPEUTICS
审中-公开
用反义寡核苷酸和丝氨酸作为抗炎剂治疗剂抑制细胞凋亡特异性ELF-5A（“EIF-5A1”）
- Patent Title: INHIBITION OF APOPTOSIS-SPECIFIC ELF-5A ("EIF-5A1") WITH ANTISENSE OLIGONUCLEOTIDES AND SIRNAS AS ANTI-INFLAMMATORY THERAPEUTICS
- Patent Title (中): 用反义寡核苷酸和丝氨酸作为抗炎剂治疗剂抑制细胞凋亡特异性ELF-5A（“EIF-5A1”）
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Application No.: PCT/US2004018012Application Date: 2004-06-07
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Publication No.: WO2005007853A3Publication Date: 2005-10-27
- Inventor: THOMPSON JOHN E , TAYLOR CATHERINE
- Applicant: SENESCO TECHNOLOGIES INC , THOMPSON JOHN E , TAYLOR CATHERINE
- Assignee: SENESCO TECHNOLOGIES INC,THOMPSON JOHN E,TAYLOR CATHERINE
- Current Assignee: SENESCO TECHNOLOGIES INC,THOMPSON JOHN E,TAYLOR CATHERINE
- Priority: US47619403 2003-06-06; US50473103 2003-09-22; US52824903 2003-12-10; US55767104 2004-03-31; US57581404 2004-06-02
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C12N15/113 ; C12N15/11 ; A61K31/713 ; A61P27/00 ; A61P37/00
Abstract:
The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
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