Invention Application
WO2005040418A3 COMPOSITIONS FOR DIAGNOSIS AND THERAPY OF DISEASES ASSOCIATED WITH ABERRANT EXPRESSION OF FUTRINS (R-SPONDINS) AND/OR WNT
审中-公开
用于诊断和治疗与FUTRINS（R-SPONDINS）和/或WNT的ABERRANT表达相关的疾病的组合物
- Patent Title: COMPOSITIONS FOR DIAGNOSIS AND THERAPY OF DISEASES ASSOCIATED WITH ABERRANT EXPRESSION OF FUTRINS (R-SPONDINS) AND/OR WNT
- Patent Title (中): 用于诊断和治疗与FUTRINS（R-SPONDINS）和/或WNT的ABERRANT表达相关的疾病的组合物
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Application No.: PCT/EP2004011269Application Date: 2004-10-08
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Publication No.: WO2005040418A3Publication Date: 2005-11-10
- Inventor: NIEHRS CHRISTOF , WU WEI , GLINKA ANDREI , KAZANSKAYA OLGA
- Applicant: DEUTSCHES KREBSFORSCH , NIEHRS CHRISTOF , WU WEI , GLINKA ANDREI , KAZANSKAYA OLGA
- Assignee: DEUTSCHES KREBSFORSCH,NIEHRS CHRISTOF,WU WEI,GLINKA ANDREI,KAZANSKAYA OLGA
- Current Assignee: DEUTSCHES KREBSFORSCH,NIEHRS CHRISTOF,WU WEI,GLINKA ANDREI,KAZANSKAYA OLGA
- Priority: EP03023000 2003-10-10
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K14/47 ; C07K14/78 ; C12Q1/68
Abstract:
The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4(= R-Spondin 2, 3, 1 and 4, respectively), e.g. in connection with tumors or diseases of the muscle, kidneys or bones. The present invention also relates to a pharmaceutical composition containing a compound which is capable of modifying (a) the expression of the gene encoding Futrin 1, 2, 3 and/or 4 or (b) the activity of the Futrin 1, 2, 3 and/or 4 protein.
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