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    ANTI-CEACAM6 ANTIBODIES AND USES THEREOF
    1.
    发明申请
    ANTI-CEACAM6 ANTIBODIES AND USES THEREOF 审中-公开
    抗-CACACAM6抗体及其用途

    公开(公告)号：WO2016150899A3

    公开(公告)日：2016-11-17

    申请号：PCT/EP2016056104

    申请日：2016-03-21

    Applicant: BAYER PHARMA AG ,  DEUTSCHES KREBSFORSCH

    Inventor： WILLUDA JÖRG ,  TRAUTWEIN MARK ,  GRITZAN UWE ,  FREIBERG CHRISTOPH ,  DITTMER FRANK ,  SCHÖNFELD DORIAN ,  GLÜCK JULIAN MARIUS ,  BRUDER JESSICA ,  SCHLECKER EVA-MARIA ,  GOLFIER SVEN ,  HOLTON SIMON ,  BECKHOVE PHILIP ,  GE YINGZI

    IPC: C07K16/28 ,  A61P35/00

    CPC classification number: C07K16/2803 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    Abstract: The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies. The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

    Abstract translation: 本公开提供了重组抗原结合区和包含对人和猕猴属CEACAM6特异性的这种抗原结合区的抗体和功能片段（癌胚抗原相关细胞粘附分子6，CD66c，非特异性交叉反应抗原，NCA，NCA -50/90），并且与密切相关的人类CEACAM1，人类CEACAM3和人类CEACAM5不显着交叉反应。 本公开进一步提供了产生这种抗体的方法。 因此，抗体可用于治疗与CEACAM6表达相关的癌症和其它病症和病症。 本公开还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。

    NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION
    5.
    发明申请
    NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION 审中-公开
    新的酰胺类化合物及其作为抗血管生成和成骨细胞形成的抑制剂

    公开(公告)号：WO2012093091A3

    公开(公告)日：2012-10-11

    申请号：PCT/EP2012000040

    申请日：2012-01-05

    Applicant: DEUTSCHES KREBSFORSCH ,  SCHWARTZ-ALBIEZ REINHARD ,  MARANO GRAZIA ,  FREI EVA ,  FRANK MARTIN ,  MEISTER BETINA

    Inventor： SCHWARTZ-ALBIEZ REINHARD ,  MARANO GRAZIA ,  FREI EVA ,  FRANK MARTIN ,  MEISTER BETINA

    IPC: C07H15/26 ,  A61K31/7048 ,  A61P35/04

    CPC classification number: C07H15/26

    Abstract: The present invention relates to saccharide mimics which show a better biological activity at low concentrations as known saccharide mimics in inhibiting angiogenesis and inhibiting formation of metastasis by inhibiting adhesion and/or migration of human cancer cells, particularly in concentrations lower than 5 mM, and to pharmaceutical compositions comprising these saccharide mimics. The compounds of the present invention are useful as mimics of cell surface structures and, thus, for influencing cell-cell and cell-extracellular (ECM) interactions, which are controlled by bonds between protein-protein, saccharide-saccharide or saccharide-lectin on the cell - surface. Exemplary compounds are: formulae (I), (II), (III), (IV).

    Abstract translation: 本发明涉及糖模拟物，其在低浓度下表现出较好的生物学活性，作为已知的糖类模拟物，通过抑制人癌细胞的粘附和/或迁移，特别是低于5mM的浓度，抑制血管生成并抑制转移的形成， 包含这些糖模拟物的药物组合物。 本发明的化合物可用作细胞表面结构的模拟物，并因此用于影响由蛋白质 - 蛋白质，糖 - 糖或糖 - 凝集素之间的键控制的细胞 - 细胞和细胞 - 细胞外（ECM）相互作用 细胞表面。 示例性化合物为：式（I），（II），（III），（IV）。

    MODIFIED RODENT PARVOVIRUS CAPABLE OF PROPAGATING AND SPREADING THROUGH HUMAN GLIOMAS
    7.
    发明申请
    MODIFIED RODENT PARVOVIRUS CAPABLE OF PROPAGATING AND SPREADING THROUGH HUMAN GLIOMAS 审中-公开
    通过人类胶质瘤能够传播和传播的修饰的鼠类纵隔病毒

    公开(公告)号：WO2011138053A3

    公开(公告)日：2012-03-15

    申请号：PCT/EP2011002306

    申请日：2011-05-09

    Applicant: DEUTSCHES KREBSFORSCH ,  NUEESCH JUERG ,  THOMAS NADJA ,  PLOTZKY CLAUDIA ,  ROMMELAERE JEAN

    Inventor： NUEESCH JUERG ,  THOMAS NADJA ,  PLOTZKY CLAUDIA ,  ROMMELAERE JEAN

    IPC: A61K35/76 ,  C12N7/00

    CPC classification number: C12N7/02 ,  A61K35/768 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14322 ,  C12N2750/14332 ,  C12N2750/14343

    Abstract: Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in semi-permissive human tumor cells, and (b) parvovirus variants capable of propagating and spreading through human tumor cells characterized by particular amino acid deletions and/or substitutions, e.g. a deletion of several amino acids in the C-terminus of NS1/middle exon of NS2. A pharmaceutical composition containing such parvoviruses as well as their use for the treatment of cancer, preferably a glioblastoma, is also described.

    Abstract translation: 描述了（a）能够通过人肿瘤细胞繁殖和扩散的细小病毒变体，其可通过在半人允许的人肿瘤细胞中将啮齿动物细小病毒作为起始菌株进行连续传代获得，和（b）能够通过人肿瘤增殖和传播的细小病毒变体 以特定氨基酸缺失和/或取代为特征的细胞， 在NS2的C-末端的NS2 /中间外显子的几个氨基酸的缺失。 还描述了包含这种细小病毒的药物组合物以及它们用于治疗癌症，优选胶质母细胞瘤的用途。

    MODIFIED AAV CAPSID POLYPEPTIDES
    9.
    发明申请
    MODIFIED AAV CAPSID POLYPEPTIDES 审中-公开
    改良AAV CAPSID多糖

    公开(公告)号：WO2010136549A3

    公开(公告)日：2011-02-17

    申请号：PCT/EP2010057370

    申请日：2010-05-28

    Applicant: DEUTSCHES KREBSFORSCH ,  UNIV RUPRECHT KARLS HEIDELBERG ,  MUELLER OLIVER ,  KATUS HUGO ,  VARADI KARL ,  KLEINSCHMIDT JUERGEN

    Inventor： MUELLER OLIVER ,  KATUS HUGO ,  VARADI KARL ,  KLEINSCHMIDT JUERGEN

    IPC: C12N15/864

    CPC classification number: C07K14/005 ,  C12N2710/24143 ,  C12N2750/14122 ,  C12N2810/40

    Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.

    Abstract translation: 本发明涉及编码包含插入肽和包含所述多核苷酸的载体的AAV衣壳多肽的多核苷酸。 此外，预期包含所述多核苷酸或载体的宿主细胞，制备所述衣壳多肽的方法以及所述多肽。 进一步包括与所述多肽特异性结合的抗体和包含所述多核苷酸，载体，多肽或抗体的药物。 还考虑了所述多核苷酸，载体，多肽或抗体在制备用于治疗血管疾病的药物中的用途以及鉴定与所述多肽结合的化合物的方法。

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