发明申请
WO2006128268A8 UREIDIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE ON THE TREATMENT OF INFLAMMATORY DISEASES
审中-公开
尿素化合物，含有该化合物的药物组合物及其在治疗炎症疾病中的应用
- 专利标题： UREIDIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE ON THE TREATMENT OF INFLAMMATORY DISEASES
- 专利标题（中）： 尿素化合物，含有该化合物的药物组合物及其在治疗炎症疾病中的应用
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申请号： PCT/BR2006000107申请日： 2006-06-01
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公开(公告)号： WO2006128268A8公开(公告)日： 2007-04-26
- 发明人: LACERDA BARREIRO ELIEZER JESUS , MANSSOUR FRAGA CARLOS ALBERTO , SPERANDIO DA SILVA GILBERTO MA , MOREIRA LIMA LIDIA , MEDEIROS DE CARVALHO FATIMA , MENEZES QUINTAS LUIS EDUARDO , LEGORA MACHADO ALEXANDRE , GONCALVES KOATZ VERA LUCIA
- 申请人： UNIV RIO DE JANEIRO , LACERDA BARREIRO ELIEZER JESUS , MANSSOUR FRAGA CARLOS ALBERTO , SPERANDIO DA SILVA GILBERTO MA , MOREIRA LIMA LIDIA , MEDEIROS DE CARVALHO FATIMA , MENEZES QUINTAS LUIS EDUARDO , LEGORA MACHADO ALEXANDRE , GONCALVES KOATZ VERA LUCIA
- 专利权人： UNIV RIO DE JANEIRO,LACERDA BARREIRO ELIEZER JESUS,MANSSOUR FRAGA CARLOS ALBERTO,SPERANDIO DA SILVA GILBERTO MA,MOREIRA LIMA LIDIA,MEDEIROS DE CARVALHO FATIMA,MENEZES QUINTAS LUIS EDUARDO,LEGORA MACHADO ALEXANDRE,GONCALVES KOATZ VERA LUCIA
- 当前专利权人： UNIV RIO DE JANEIRO,LACERDA BARREIRO ELIEZER JESUS,MANSSOUR FRAGA CARLOS ALBERTO,SPERANDIO DA SILVA GILBERTO MA,MOREIRA LIMA LIDIA,MEDEIROS DE CARVALHO FATIMA,MENEZES QUINTAS LUIS EDUARDO,LEGORA MACHADO ALEXANDRE,GONCALVES KOATZ VERA LUCIA
- 优先权： BRPI0502016 2005-06-03
- 主分类号： C07D491/056
- IPC分类号： C07D491/056 ; C07D491/14 ; A61K31/4741 ; A61P29/00 ; C07C275/38
摘要：
The present invention describes functionalizeds derivatives of ethyl 6-N- alkyl and/or 6-N-aryl ureas [1 ,3]dioxolo[5,4-g]quinolin-7-carboxylate (3a-z, 4a-z) and similar types (5a-z), of general formula (I, II, III and IV), useful in the treatment and/or prevention of inflammatory diseases, such as acute or chronic inflammatory conditions, different types of arthritis, asthma, Crohn's Disease and diabetes mellitus Type I, among others. These derivatives have the ability of modulate the inflammatory process, acting in mitogen activated protein kinase p-38 (MAPK-p38). Moreover, the derivatives of the present invention present expressive anti-inflammatory properties evaluated in in vivo models. The present invention also discloses processes for the production of such derivatives and harmaceutical com ositions containin the same.
