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    PROTEIC ACID POLYMER, PRODUCTION PROCESSES, USE OF PROTEIC ACID POLYMER, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT
    1.
    发明申请
    PROTEIC ACID POLYMER, PRODUCTION PROCESSES, USE OF PROTEIC ACID POLYMER, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT 审中-公开
    防酸聚合物，生产工艺，防酸聚合物的使用，药物组合物和处理方法

    公开(公告)号：WO2010025530A9

    公开(公告)日：2010-07-29

    申请号：PCT/BR2009000051

    申请日：2009-02-20

    申请人： UNIV RIO DE JANEIRO ,  LOBO COELHO DE SAMPAIO TATIANA

    发明人： LOBO COELHO DE SAMPAIO TATIANA

    IPC分类号： C07K14/78 ,  A61K38/39

    CPC分类号： A61K38/39 ,  C07K14/78

    摘要： The present invention relates to proteic acid polymers (pLNs) comprising specific properties to reduce tissue damage and improve functional recovery after injury, and the production process of said proteic acid polymers. Those pLNs are preferably obtained using the protein laminin diluted in an acidic pH in the presence of divalent cation. The use of said proteic acid polymers for the production of a drug, a pharmaceutical composition containing such pLNs and a method of treatment of animals affected by traumatic, degenerative or inflammatory tissue injuries in nervous tissue, muscle, epithelial and connective tissues in general are also objects of the present invention.

    摘要翻译： 本发明涉及包含降低组织损伤并改善损伤后功能恢复的特定性质的蛋白酸聚合物（pLN）以及所述蛋白酸聚合物的生产方法。 那些pLN优选使用在二价阳离子存在下在酸性pH下稀释的蛋白质层粘连蛋白获得。 通常使用所述蛋白酸聚合物生产药物，含有这种pLN的药物组合物和治疗受神经组织，肌肉，上皮和结缔组织中的创伤性，退行性或炎性组织损伤影响的动物的方法 本发明的目的。

    DENV-DERIVED PEPTIDES AND METHODS FOR THE INHIBITION OF THE FLAVIVIRUS REPLICATION
    6.
    发明申请
    DENV-DERIVED PEPTIDES AND METHODS FOR THE INHIBITION OF THE FLAVIVIRUS REPLICATION 审中-公开
    丹参衍生物和抑制FLAVIVIRUS再生的方法

    公开(公告)号：WO2012159187A3

    公开(公告)日：2013-07-18

    申请号：PCT/BR2012000162

    申请日：2012-05-28

    申请人： UNIV RIO DE JANEIRO ,  UNIV LISBOA ,  INST DE MEDICINA MOLECULAR ,  DE ALMEIDA FABIO CENEVIVA LACERDA ,  DA ROCHA MARTINS IVO CRISTIANO ,  DA POIAN ANDREA THOMPSON ,  DOS SANTOS NUNO FERNANDO DUARTE CORDEIRO CORREIA

    发明人： DE ALMEIDA FABIO CENEVIVA LACERDA ,  DA ROCHA MARTINS IVO CRISTIANO ,  DA POIAN ANDREA THOMPSON ,  DOS SANTOS NUNO FERNANDO DUARTE CORDEIRO CORREIA

    IPC分类号： C07K14/18 ,  A61K38/04 ,  A61P31/14 ,  C07K7/06 ,  C07K7/08 ,  C07K14/005

    CPC分类号： C07K14/005 ,  C12N2770/24111 ,  C12N2770/24122

    摘要： Dengue virus (DENV) is a Flavivirus that causes the major human arbovirosis, for which no specific treatment exists. The C protein, the viral capsid protein, is a symmetric homodimeric a-helical protein that interacts with intracellular lipid droplets (LDs) during viral replication, possibly via a alpha2-alpha2' non-polar central patch that has been hypothesized to interact with lipids. The C protein binding sites to LD were identified, revealing a new function for a conserved segment in the N- terminal disordered region, and indicating that conformational selection is involved in recognition. The obtained results showed that C protein positively-charged N-terminal region prompts the interaction with negatively- charged LDs, after which a conformational rearrangement enables the access of the central hydrophobic patch to LD surface. Altogether, the results allowed the design of a peptide with inhibitory activity of C protein-LD binding, paving the way for new drug development approaches against dengue. The ability of this peptide to bind to LDs in a similar fashion to that of the C protein was demonstrated employing different techniques, such as, but not limited to, nuclear magnetic resonance, zeta potential analysis and atomic force microscopy. Moreover, the de novo designed peptides were tested regarding their ability to inhibit DENV C protein binding to LDs, having been shown that it effectively inhibits the DENV C interaction with LDs, a finding of direct applicability for dengue and related Flavivirus originated pathologies.

    摘要翻译： 登革热病毒（DENV）是一种黄病毒病毒，可导致主要的人体无症状，无特殊治疗。 病毒衣壳蛋白C蛋白是病毒复制过程中与细胞内脂质液滴（LD）相互作用的对称同二聚体α-螺旋蛋白，可能通过已经假设与脂质相互作用的α2-α2'非极性中心贴片 。 鉴定了C蛋白与LD的结合位点，揭示了N-末端无序区域中保守区段的新功能，并表明构象选择涉及识别。 得到的结果表明，C蛋白带正电的N末端区域促使与带负电荷的LDs相互作用，之后，构象重排使得中心疏水性贴片能够进入LD表面。 总之，结果允许设计具有C蛋白-LD结合的抑制活性的肽，为针对登革热的新药开发方法铺平了道路。 使用不同的技术（例如但不限于核磁共振，ζ电位分析和原子力显微镜）证明了该肽以与C蛋白类似的方式与LD结合的能力。 此外，测试了从头设计的肽对于抑制DENV C蛋白与LD结合的能力，已经显示其有效抑制与LD的DENV C相互作用，这是对登革热和相关的黄病毒起源病理学的直接适用性的发现。

    METHOD FOR OBTAINING A CULTURE SUBSTRATE FOR PLURIPOTENT STEM CELLS AND CULTURE SUBSTRATE OBTAINED BY THIS METHOD
    7.
    发明申请
    METHOD FOR OBTAINING A CULTURE SUBSTRATE FOR PLURIPOTENT STEM CELLS AND CULTURE SUBSTRATE OBTAINED BY THIS METHOD 审中-公开
    用于获得本方法获得的培养基细胞和培养基质的培养基质的方法

    公开(公告)号：WO2012167338A3

    公开(公告)日：2013-02-21

    申请号：PCT/BR2012000173

    申请日：2012-06-06

    申请人： UNIV RIO DE JANEIRO ,  KASTRUP REHEN STEVENS ,  PARANHOS STELLING MARIANA

    发明人： KASTRUP REHEN STEVENS ,  PARANHOS STELLING MARIANA

    IPC分类号： C12N5/0735 ,  C12N5/074 ,  C12N5/095 ,  C12N5/22

    CPC分类号： C12N5/0606 ,  C12N2502/13 ,  C12N2533/54

    摘要： The present invention patent application comprises a substrate for cultivating pluripotent stem cells that is produced by immobilising embryonic mouse fibroblast cells in ethanol, and the method for producing the substrate. The invention aims at providing a substrate having the necessary complexity to ensure that at least 95% of the cells remains pluripotent. Moreover, the use of feeding cell layers is replaced, culture conditions are maintained and contamination with animal molecules by the matrix is eliminated, with an inexpensive substrate that is compatible with national scientific demand.

    摘要翻译： 本发明的专利申请包括用于培养通过将胚胎小鼠成纤维细胞固定在乙醇中而产生的多能干细胞的底物和用于制备基质的方法。 本发明旨在提供具有必要复杂性的底物以确保至少95％的细胞保持多能性。 此外，替代了饲养细胞层的使用，维持培养条件并消除基质对动物分子的污染，具有与国家科学需求相适应的便宜的底物。

    USE OF PHTHALIMIDE DERIVATIVES IN THE TREATMENT OF DISEASES
    10.
    发明申请
    USE OF PHTHALIMIDE DERIVATIVES IN THE TREATMENT OF DISEASES 审中-公开
    邻苯二胺衍生物在治疗疾病中的应用

    公开(公告)号：WO2009073940A3

    公开(公告)日：2009-11-12

    申请号：PCT/BR2008000386

    申请日：2008-12-12

    申请人： UNICAMP ,  UNIV RIO DE JANEIRO ,  UNIV ESTADUAL PAULISTA JULIO D ,  DOS SANTOS JEAN LEANDRO ,  CHUNG MAN CHIN ,  MOREIRA LIMA LIDIA ,  FERREIRA COSTA FERNANDO ,  LANARO CAROLINA

    发明人： DOS SANTOS JEAN LEANDRO ,  CHUNG MAN CHIN ,  MOREIRA LIMA LIDIA ,  FERREIRA COSTA FERNANDO ,  LANARO CAROLINA

    IPC分类号： A61K31/4035 ,  C07D209/48

    CPC分类号： A61K31/4196 ,  A61K9/0019

    摘要： The present invention refers to the use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, which have important activities in increasing the gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-a levels and an exogenous source of nitric oxide. More particularly, the present invention describes the use of such phthalimide and/or sulphonamide derivatives for the treatment of sickle-cell diseases. The invention also has as a novel characteristic the disclosure of new functionalized phthalimide derivatives designed from the prototypes thalidomide and hydroxyurea, and designed rationally through the strategy of molecular hybridization for the treatment of said diseases. The invention still discloses a new method for obtaining a specific sulphonamide derivative which can be used in the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-a factor and an exogenous source of nitric oxide.

    摘要翻译： 本发明涉及具有一氧化氮供体性质的邻苯二甲酰亚胺和/或磺酰胺衍生物的用途，其具有增加γ珠蛋白基因表达和抗炎和止痛活性的重要活性，其有效治疗需要减少的血液学疾病 TNF-α水平和一氧化氮的外源性来源。 更具体地，本发明描述了这种邻苯二甲酰亚胺和/或磺酰胺衍生物在治疗镰状细胞疾病中的用途。 本发明还具有从原型沙利度胺和羟基脲设计的新的官能化邻苯二甲酰亚胺衍生物的新颖特征，并通过分子杂交策略合理设计用于治疗所述疾病。 本发明还公开了一种获得特异性磺酰胺衍生物的新方法，其可用于制备用于治疗需要降低TNF-α因子和外源性一氧化氮水平的疾病的药物。