Invention Application
WO2006136429A1 COMPOUNDS FOR THE TREATMENT OF NON-AUTOIMMUNE TYPE 2 DIABETES MELLITUS AND/OR SYNDROME X
审中-公开
用于治疗非自身免疫型2型糖尿病和/或综合征X的化合物
- Patent Title: COMPOUNDS FOR THE TREATMENT OF NON-AUTOIMMUNE TYPE 2 DIABETES MELLITUS AND/OR SYNDROME X
- Patent Title (中): 用于治疗非自身免疫型2型糖尿病和/或综合征X的化合物
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Application No.: PCT/EP2006/006049Application Date: 2006-06-23
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Publication No.: WO2006136429A1Publication Date: 2006-12-28
- Inventor: D'ORAZIO, Daniel , DE SAIZIEU, Antoine , RAEDERSTORFF, Daniel , SCHUELER, Göde , WANG-SCHMIDT, Ying , WEHRLI, Christof , WERTZ, Karin , WOLFRAM, Swen
- Applicant: DSM IP ASSETS B.V. , D'ORAZIO, Daniel , DE SAIZIEU, Antoine , RAEDERSTORFF, Daniel , SCHUELER, Göde , WANG-SCHMIDT, Ying , WEHRLI, Christof , WERTZ, Karin , WOLFRAM, Swen
- Applicant Address: Het Overloon 1, NL-6411 TE Heerlen NL
- Assignee: DSM IP ASSETS B.V.,D'ORAZIO, Daniel,DE SAIZIEU, Antoine,RAEDERSTORFF, Daniel,SCHUELER, Göde,WANG-SCHMIDT, Ying,WEHRLI, Christof,WERTZ, Karin,WOLFRAM, Swen
- Current Assignee: DSM IP ASSETS B.V.,D'ORAZIO, Daniel,DE SAIZIEU, Antoine,RAEDERSTORFF, Daniel,SCHUELER, Göde,WANG-SCHMIDT, Ying,WEHRLI, Christof,WERTZ, Karin,WOLFRAM, Swen
- Current Assignee Address: Het Overloon 1, NL-6411 TE Heerlen NL
- Agency: PRESSNER, Dietmar et al.
- Priority: EP05 20050624
- Main IPC: C07H15/04
- IPC: C07H15/04
Abstract:
The present invention relates to compounds of the formula (I); wherein R 1 Js H, CH 3 or OCH 3 ; R 3 = H, OH, CH 3 , OCH 3 , O-glucose or benzoyloxy; R 4 = H; R 5 = H or OH; R 6 = H or OCH 3 ; R 7 = H, CH 3 , OCH 3 , cinnamoyloxy or (3,4,5-trimethoxy)-benzoyloxy; R 8 = H, OH, CH 3 or OCH3; or R 7 and R 8 form together a group 0-CH 2 -O; R 9 = H or OCH 3 ; R 10 = H or N-acetyl, N-methyl-2-aminoethyl; to their use as medicament for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X, to dietary and pharmaceutical compositions containing them and to a method for the treatment of non-autoimmune type 2 diabetes mellitus and/or syndrome X in animals including humans, said method comprising the step of administering an effective dose of a compound of the formula (I) to animals including humans which are in need thereof.
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