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    USE OF HYDROXYTYROSOL FOR IMPROVING MUSCLE DIFFERENTIATION
    1.
    发明申请
    USE OF HYDROXYTYROSOL FOR IMPROVING MUSCLE DIFFERENTIATION 审中-公开
    用于改善肌肉分化的羟肟酸的使用

    公开(公告)号：WO2011041937A1

    公开(公告)日：2011-04-14

    申请号：PCT/CN2010/001550

    申请日：2010-10-08

    Applicant: DSM IP Assets, B.V. ,  Liu, Jiankang ,  Wang-Schmidt, Ying ,  Wertz, Karin ,  Feng, Zhihui

    Inventor： Liu, Jiankang ,  Wang-Schmidt, Ying ,  Wertz, Karin ,  Feng, Zhihui

    IPC: A61K31/05 ,  A61P21/02

    CPC classification number: A61K31/05 ,  A23L2/52 ,  A23L33/105 ,  A61K36/63

    Abstract: The use of hydroxytyrosol or an olive juice extract containing hydroxytyrosol for improving muscle differentiation and thus improving or maintaining the body's adaptation to exercise is disclosed. The pharmaceutical and nutraceutical compositions comprising hydroxytyrosol useful for conditions characterized by altered muscle differentiation especially under inflammatory conditions, such as delayed onset muscle soreness subsequent to strenuous exercise or sarcopenia are provided.

    Abstract translation: 公开了使用羟基酪醇或含有羟基酪醇的橄榄汁提取物来改善肌肉分化，从而改善或维持身体适应运动。 提供了包含羟基酪醇的药物和营养组合物，其用于特征在于肌炎分化改变的病症，特别是在炎症状态下，例如剧烈运动或肌肉减少症后延迟发作的肌肉酸痛。

    NOVEL USE OF HYDROXYTYROSOL AND OLIVE EXTRACTS/CONCENTRATES CONTAINING IT
    7.
    发明申请
    NOVEL USE OF HYDROXYTYROSOL AND OLIVE EXTRACTS/CONCENTRATES CONTAINING IT 审中-公开
    使用羟肟酸和橄榄提取物/含有浓度的浓缩物

    公开(公告)号：WO2008128552A1

    公开(公告)日：2008-10-30

    申请号：PCT/EP2007/003405

    申请日：2007-04-18

    Applicant: DSM IP ASSETS B.V. ,  LIU, Jiankang ,  SCHALCH, Wolfgang ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

    Inventor： LIU, Jiankang ,  SCHALCH, Wolfgang ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin

    IPC: A61K31/05

    CPC classification number: A61K31/05 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/2132

    Abstract: The present invention is directed to the use of (a composition comprising) hydroxytyrosol for treating or preventing age-related macular degeneration in humans, for maintaining the eye health in animals (preferably in humans), especially in elderly animals (preferably elderly humans), for improving the vision of animals (preferably of humans), for maintaining the high resolution vision in animals (preferably in humans) and/or for maintaining the visual acuity in animals (preferably in humans), as well as for maintaining the visual performance in animals (preferably in humans) and/or the visual function in animals (preferably in humans).

    Abstract translation: 本发明涉及用于治疗或预防人类年龄相关性黄斑变性的（含有羟基酪氨酸的组合物）用于维持动物（优选人）中的眼睛健康的用途，特别是在老年动物（优选老年人）中， 为了维持动物（优选人类）中的高分辨率视觉和/或维持动物（优选人类）中的视力，以及维持动物（优选人类）的视力，以及维持动物 动物（优选人）和/或动物（优选人类）中的视觉功能。

    TREATING MUSCULAR DISORDERS AND IMPROVING MUSCULAR FUNCTION
    8.
    发明申请
    TREATING MUSCULAR DISORDERS AND IMPROVING MUSCULAR FUNCTION 审中-公开

    公开(公告)号：WO2007134867A3

    公开(公告)日：2007-11-29

    申请号：PCT/EP2007/004627

    申请日：2007-05-24

    Applicant: DSM IP ASSETS B.V. ,  D'ORAZIO, Daniel ,  RAEDERSTORFF, Daniel ,  SCHUELER, Goede ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin ,  WOLFRAM, Swen

    Inventor： D'ORAZIO, Daniel ,  RAEDERSTORFF, Daniel ,  SCHUELER, Goede ,  WANG-SCHMIDT, Ying ,  WERTZ, Karin ,  WOLFRAM, Swen

    IPC: A61P21/00 ,  A61P9/00 ,  A61P9/10 ,  A61P19/02 ,  A61P1/00 ,  A61K31/166 ,  A61K31/12 ,  A61K31/352 ,  A23L1/30

    Abstract: The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy,, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle : fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.

    NOVEL USE OF ORGANIC COMPOUNDS
    9.
    发明申请
    NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
    有机化合物的新用途

    公开(公告)号：WO2007134867A2

    公开(公告)日：2007-11-29

    申请号：PCT/EP2007004627

    申请日：2007-05-24

    Applicant: DSM IP ASSETS BV ,  D ORAZIO DANIEL ,  RAEDERSTORFF DANIEL ,  SCHUELER GOEDE ,  WANG-SCHMIDT YING ,  WERTZ KARIN ,  WOLFRAM SWEN

    Inventor： D ORAZIO DANIEL ,  RAEDERSTORFF DANIEL ,  SCHUELER GOEDE ,  WANG-SCHMIDT YING ,  WERTZ KARIN ,  WOLFRAM SWEN

    IPC: A61P21/00 ,  A23L1/30 ,  A61K31/12 ,  A61K31/166 ,  A61K31/352 ,  A61P1/00 ,  A61P9/00 ,  A61P9/10 ,  A61P19/02

    CPC classification number: A23K20/111 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/12 ,  A61K31/166 ,  A61K31/352 ,  A23V2200/316 ,  A23V2200/328 ,  A23V2200/326 ,  A23V2200/318 ,  A23V2200/32

    Abstract: The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy,, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle : fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.

    Abstract translation: 本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物 的肌肉功能。 其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病 ，类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如肠炎综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘 ，慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。 这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。 本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有 这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。 本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

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