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发明申请
WO2007058346A1 I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 审中-公开
具有11-β-羟基脱氢酶脱氢酶I型抑制活性的杂环化合物

I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物
摘要：
Disclosed is a compound represented by the formula below or a pharmaceutically acceptable salt thereof or a solvate of the compound or the salt, which is useful as an inhibitor of 11-ß-hydroxysteroid dehydrogenase type I. wherein R 1 represents an alkyl which may be substituted or the like; one of R 2 and R 4 represents a group represented by the formula: -Y-R 5 [wherein Y represents -O- or the like, and R 5 represents a substituted alkyl (in which the substituent is a cycloalkyl which may be substituted or the like), a branched alkyl which may be substituted or the like], and the other of R 2 and R 4 represents a hydrogen or an alkyl which may be substituted; R 3 represents a group represented by the formula: -C(=O)-Z-R 6 (wherein Z represents a group represented by -NR 7 - or -NR 7 -W-, R 6 represents a cycloalkyl which may be substituted or the like, R 7 represents a hydrogen or an alkyl which may be substituted, and W represents an alkylene which may be substituted); and X represents =N- or the like, provided that a combination of a 2-(morpholino)etoxy as R 2 , an N-(1-adamantyl)carbamoyl as R 3 and a benzyl as R 1 is excluded.
摘要（中）：

公开了由下式表示的化合物或其药学上可接受的盐或化合物或其盐的溶剂合物，其可用作I型11-β-羟基类固醇脱氢酶I的抑制剂。其中R 1〜 >表示可以被取代的烷基等; R 2和R 4之一表示由下式表示的基团：-YR 5 [其中Y表示-O-等， 和R 5表示取代的烷基（其中取代基是可被取代的环烷基等），可被取代的支链烷基等]，另一个R 2和R 4表示氢或可被取代的烷基; R 3表示由下式表示的基团：-C（= O）-ZR 6（其中Z表示由-NR 7 O表示的基团 > - 或-NR 7 -W-，R 6表示可以被取代或等同的环烷基，R 7表示氢或 可被取代的烷基，W表示可被取代的亚烷基）; 并且X表示= N-等，条件是2-（吗啉代）乙氧基作为R 2，N-（1-金刚烷基）氨基甲酰基，R 3， SUP＆gt;和作为R 1的苄基被排除。

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