发明申请
- 专利标题： CHEMICALLY DERIVATIZED CD4 AND USES THEREOF
- 专利标题（中）： 化学衍生的CD4及其用途
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申请号： PCT/US2006/047907申请日： 2006-12-14
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公开(公告)号： WO2007075414A2公开(公告)日： 2007-07-05
- 发明人: HENDRICKSON, Wayne, A. , XIE, Hui , SMITH, Amos, B. , NG, Danny
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , HENDRICKSON, Wayne, A. , XIE, Hui , SMITH, Amos, B. , NG, Danny
- 申请人地址： West 116th Street And Broadway, New York, NY 10027 US
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK,THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA,HENDRICKSON, Wayne, A.,XIE, Hui,SMITH, Amos, B.,NG, Danny
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK,THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA,HENDRICKSON, Wayne, A.,XIE, Hui,SMITH, Amos, B.,NG, Danny
- 当前专利权人地址： West 116th Street And Broadway, New York, NY 10027 US
- 代理机构： WHITE, John, P.
- 优先权： US60/750,464 20051214; US60/789,467 20060404
- 主分类号： C07K16/10
- IPC分类号： C07K16/10 ; A61K39/42
摘要：
This invention provides two soluble polypeptides which comprise a portion of CD4 comprising all HIV gpl20-binding epitopes present on intact CD4, wherein the polypeptide has a cysteine substitution at a residue which, in intact CD4, interfaces with HIV gpl20. This invention provides also provides a method for making a derivatized soluble polypeptide and a method for obtaining a structural model useful in the design of an agent for inhibiting CD4 binding to HIV gpl20.
