公开(公告)号：WO2023084055A1

公开(公告)日：2023-05-19

申请号：PCT/EP2022/081676

申请日：2022-11-11

Applicant: RQ BIOTECHNOLOGY LIMITED

Inventor： SAWMYNADEN, Kovilen

IPC: C07K16/10

Abstract: The present invention relates to antibodies capable of binding to the spike protein of coronavirus SARS-CoV-2, and methods and uses thereof in the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19.

公开(公告)号：WO2023081471A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/049142

申请日：2022-11-07

Applicant: DANA-FARBER CANCER INSTITUTE, INC. ,  ABVIRO LLC

Inventor： MARASCO, Wayne A. ,  RAMSTEDT, Hans Urban

IPC: C07K16/10 ,  A61P31/12

Abstract: The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection.

公开(公告)号：WO2023079137A1

公开(公告)日：2023-05-11

申请号：PCT/EP2022/080965

申请日：2022-11-07

Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN ,  VIB VZW ,  UNIVERSITEIT GENT

Inventor： GEUKENS, Nick ,  DECLERCK, Paul ,  IMBRECHTS, Maya ,  AMPOFO, Louanne ,  MAES, Wim ,  NEYTS, Johan ,  ABDELNABI, Rana ,  EECKHAUT, Hannah ,  CALLEWAERT, Nico ,  FIJALKOWSKA, Daria

IPC: C07K16/10 ,  A61K39/395 ,  A61P31/14 ,  C12N15/13 ,  A61K2039/505 ,  A61K2039/53 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to antibodies or antigen binding fragments thereof, specifically binding to the trimeric spike protein of Wuhan Covid-SARS-2 and specifically binding to the RBD domain of all of Wuhan, alpha, beta, gamma, delta and omicron variant of Covid-SARS-2 spike protein, characterized in that said antibody or antigen binding fragment thereof has an IC50 in a SARS-CoV-2 pseudovirus infection lower than 1 nm in a SARS-CoV-2 pseudovirus infection, and in that said antibody or antigen binding fragment thereof has an affinity for RBD domain Wuhan Covid-SARS-2 spike protein with a KD of less than 500 pM, and in that said antibody or antigen binding fragment thereof has an affinity for trimeric spike protein of Wuhan Covid-SARS-2 with a KD of less than 300 pM.

公开(公告)号：WO2023077061A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078863

申请日：2022-10-28

Applicant: WEINER, David ,  PURWAR, Mansi ,  KULKARNI, Abhijeet ,  PARK, Daniel ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

Inventor： WEINER, David ,  PURWAR, Mansi ,  KULKARNI, Abhijeet ,  PARK, Daniel ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

IPC: C07K16/28 ,  A61K39/395 ,  A61K47/68 ,  A61P37/02 ,  C07K16/10

Abstract: An advance on monoclonal technology is the development of bispecific T cell engagers (BITE) which combine the specificity of monoclonal antibodies with the cytotoxic potential of T cells. Disclosed herein are compositions comprising a recombinant nucleic acid sequence encoding a bispecific anti-HIV natural killer engager, a fragment thereof, a variant thereof, or a combination thereof, and methods of use thereof.

公开(公告)号：WO2023064435A2

公开(公告)日：2023-04-20

申请号：PCT/US2022/046513

申请日：2022-10-13

Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION ,  DUKE UNIVERSITY

Inventor： ALT, Frederick W. ,  LUO, Sai ,  SAUNDERS, Kevin ,  HAYNES, Barton F.

IPC: C07K16/10 ,  A61K39/42

Abstract: Described herein are antibody reagents that bind therapeutic targets such as SARS-COV2 spike protein, as well as methods of using such antibody reagents.

公开(公告)号：WO2023060483A1

公开(公告)日：2023-04-20

申请号：PCT/CN2021/123587

申请日：2021-10-13

Applicant: 清华大学 ,  辽宁成大生物股份有限公司

Inventor： 刘刚 ,  李雪媛 ,  高军 ,  杨俊伟 ,  张伟

IPC: A61K39/385 ,  A61K39/215 ,  A61K39/39 ,  A61P31/14 ,  C07K16/10 ,  C07K16/06

Abstract: 本发明提出了多肽免疫偶联物及其应用，该多肽免疫偶联物包括：多肽和新型冠状病毒S蛋白的RBD；其中，所述多肽与新型冠状病毒S蛋白的RBD的摩尔比为15：1～1：1。

公开(公告)号：WO2023060051A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/077493

申请日：2022-10-04

Applicant: PLANTVAX, INC.

Inventor： ROSENBERG, Yvonne

IPC: A61P31/14 ,  A61K39/00 ,  C07K16/10 ,  A61K2039/505 ,  C07K16/1063 ,  C07K2317/13 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/72 ,  C07K2317/90

Abstract: Disclosed herein are methods of producing a therapeutic plant antibody or fragment thereof, which is produced in a plant or plant cell to provide a plant antibody or fragment thereof that is unable to substantially cross the placenta if administered to a pregnant mother, but that if produced in a mammal or mammalian cell may cross the placenta and potentially result in damage to a foetus or newborn if administered to a pregnant mother, and so is suitable for use in pregnant subjects. The therapeutic plant antibody can also be used in compositions and medicaments for treating various conditions.

公开(公告)号：WO2023059900A2

公开(公告)日：2023-04-13

申请号：PCT/US2022/046089

申请日：2022-10-07

Applicant: INVIVYD, INC.

Inventor： DABORA, Rebecca ,  RATNASWAMY, Gayathri ,  MARTIN-MOE, Sheryl ,  MANNING, Mark, Cornell ,  HOLCOLM, Ryan

IPC: C07K16/10 ,  A61K39/42

Abstract: The present disclosure is directed to pharmaceutical formulations comprising antibodies, and antigen binding fragments thereof, having binding specificity for the S protein of coronaviruses (CoV-S). Other embodiments of the disclosure include the use of pharmaceutical formulations for the diagnosis, assessment, and treatment of diseases and disorders associated with coronaviruses, or the S protein thereof, and conditions where neutralization or inhibition of coronaviruses, or the S protein thereof, would be therapeutically and/or prophylactically beneficial.

公开(公告)号：WO2023043880A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/043598

申请日：2022-09-15

Applicant: COTROPIA, Joseph

Inventor： CHANDRA, Gaurav

IPC: C07K16/10 ,  A61P31/18 ,  A61K39/395

Abstract: Described are novel HIV-binding peptides and methods of using them for treating or preventing HIV infection and/or the development of AIDS.

公开(公告)号：WO2023040834A1

公开(公告)日：2023-03-23

申请号：PCT/CN2022/118493

申请日：2022-09-13

Applicant: 中国科学院微生物研究所

Inventor： 王奇慧 ,  高福 ,  刘红辉 ,  韩鹏程 ,  仵丽丽

IPC: C07K16/10 ,  C12N15/13 ,  A61K39/42 ,  A61P31/14

Abstract: 提供了一种与SARS-CoV-2 RBD结合的羊驼源纳米抗体及其应用，该纳米抗体能有效抑制SARS-CoV-2假病毒感染，可用于预防、治疗和/或检测SARS-CoV-2感染。