A temperature-controlled vehicle includes a driving portion including an engine powering the vehicle for movement. The temperature-controlled vehicle further includes a cargo portion including a load space, a heat exchanger in communication with the load space, a cryogen refrigeration circuit in communication with the heat exchanger, a fossil fuel heater selectively providing heat to the load space, a control system interactively coupled with the cryogen refrigeration circuit and the fossil fuel heater to control the temperature within the load space, and an electrical power supply disposed on the cargo portion and coupled to the fossil fuel heater and the control system to selectively provide electrical power thereto.