Invention Application
- Patent Title: FUNCTIONALIZATION OF NANOFLUIDIC CHANNELS
- Patent Title (中): 纳米通道的功能化
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Application No.: PCT/US2006/026318Application Date: 2006-07-06
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Publication No.: WO2008048209A2Publication Date: 2008-04-24
- Inventor: YANG, Peidong , KARNIK, Rohit , CASTELINO, Kenneth , FAN, Rong , MANJUMDAR, Arun
- Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , YANG, Peidong , KARNIK, Rohit , CASTELINO, Kenneth , FAN, Rong , MANJUMDAR, Arun
- Applicant Address: 1111 Franklin Street, 11th Floor Oakland, CA 94607 US
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,YANG, Peidong,KARNIK, Rohit,CASTELINO, Kenneth,FAN, Rong,MANJUMDAR, Arun
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,YANG, Peidong,KARNIK, Rohit,CASTELINO, Kenneth,FAN, Rong,MANJUMDAR, Arun
- Current Assignee Address: 1111 Franklin Street, 11th Floor Oakland, CA 94607 US
- Agency: O'BANION, John, P. et al.
- Priority: US60/697,332 20050706
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.
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