公开(公告)号：WO2023091755A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/050580

申请日：2022-11-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： ALAM, Mohammad-Reza ,  KELLY, Michael Lanam ,  GASSER-BRENNAN, Aeden Peter ,  DROZ, Etienne Robin ,  HENDRY, Jacob Ivan

IPC: C02F1/44 ,  C02F103/08

Abstract: Wave powered water desalination systems including a rotary crankshaft, a mooring spool coupled with the rotary crankshaft, at least four cylinders connected to the rotary crankshaft, wherein each of the at least four cylinders includes an inlet port for receiving salinized water and an outlet port for providing pressurized salinized water, and a reverse osmosis (RO) membrane component including a housing and a RO membrane, wherein a first side of the RO membrane component is connected to the outlet ports of the at least four cylinders. In use, with the mooring spool attached to an anchor on a seabed or to a surge flap, an oscillatory force of around 4-60 rpm is applied to the rotary crankshaft via the mooring spool, and pressurize salinized water at about 800 psi or greater is provided via the outlet ports to the RO membrane component from the at least four cylinders.

公开(公告)号：WO2023086552A2

公开(公告)日：2023-05-19

申请号：PCT/US2022/049676

申请日：2022-11-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： ORTIZ URDA, Susana ,  FEICHTENSCHLAGER, Valentin ,  VUJIC, Igor ,  SANLORENZO, Martina ,  CHEN, Emily ,  COPPE, Jean-Philippe

IPC: C12N15/113 ,  A61K31/7115 ,  A61K31/7125 ,  A61K48/00 ,  A61P35/00 ,  G01N33/574

Abstract: The invention provides compositions and methods for treatment of melanoma and other cancers. In particular, the invention provides a single or double-stranded nucleic acid that inhibits a certain group of long non-coding RNAs (lncRNAs) that have been discovered to be associated with melanoma. Inhibition of these lncRNAs in melanoma cells and xenograft mouse models leads to inhibition of cell proliferation, induction of apoptosis, and reduced cancer cell growth. The invention also relates to a method of inhibiting cancer cell growth with specific kinase inhibitors that have been found to show similar inhibition effects as the nucleic acids targeting the lncRNAs. The single or double-stranded nucleic acid and the specific kinase inhibitors constitute a novel therapeutic strategy in the treatment of melanoma and other cancers.

公开(公告)号：WO2023081762A2

公开(公告)日：2023-05-11

申请号：PCT/US2022/079227

申请日：2022-11-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  SALK INSTITUTE FOR BIOLOGICAL STUDIES

Inventor： BHATT, Ami S. ,  DURRANT, Matthew G. ,  TYCKO, Joshua C. ,  HSU, Patrick D. ,  FANTON, Alison ,  BASSIK, Michael C. ,  BINTU, Lacramioara

IPC: G16B30/10 ,  G16B40/00 ,  C12N9/22 ,  C12N15/52

Abstract: Provided herein are recombinases and compositions, methods of identification and methods of using thereof.

公开(公告)号：WO2023081748A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/079206

申请日：2022-11-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： CHANG, Hang ,  MAO, Jian-Hua

IPC: C12Q1/689 ,  C12Q1/04 ,  C12Q1/6886

Abstract: A method for predicting a subject's overall survival (OS) from a breast cancer. In some embodiments, the method comprises: (a) obtaining a tissue sample from a subject suffering from a breast cancer, or suspected thereof; (b) determining a microbial abundance prognostic score (MAPS) of the tissue sample using a formula; (c) correlating the x-microbial MAPS to a predicted OS; and, (d) optionally treating the subject with a treatment regime appropriate to the predicted OS of the subject obtained from the correlating step.

公开(公告)号：WO2023081514A1

公开(公告)日：2023-05-11

申请号：PCT/US2022/049281

申请日：2022-11-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： NEL, Andre E. ,  MEI, Kuo-Ching ,  LIU, Xiangsheng ,  LIAO, Yu-Pei

IPC: A61K9/127 ,  A61K31/395 ,  A61K51/12

Abstract: In various embodiments drug delivery vehicles and uses thereof are provided. In certain embodiments the drug delivery vehicles comprise: 1) a silicasome comprising a mesoporous silica nanoparticle coated with a lipid bilayer and further comprising a CXCR4 antagonist; or 2) a liposome comprising a lipid bilayer comprising where said liposome further comprises a CXCR4 antagonist. In certain embodiments the CXCR4 antagonists are selected from the group consisting of AMD3100, AMD3465, and AMD070.

公开(公告)号：WO2023077146A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/079033

申请日：2022-11-01

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： ROGAWSKI, Michael ,  DHIR, Ashish ,  MASCAL, Mark

IPC: A61P25/08 ,  A61K8/34 ,  C08G8/22

Abstract: The present invention provides a method of treating or mitigating seizures or epilepsy comprising compounds as described herein.

公开(公告)号：WO2023076993A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078774

申请日：2022-10-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： MONTELL, Denise

IPC: C12N5/0786 ,  A61K35/12 ,  A61K35/15 ,  C07K16/28 ,  C07K16/30

Abstract: Compositions and methods are provided for treating lymphoma in an individual by targeting engineered phagocytes to lymphoma cells. In particular, the phagocytes provided for administration to an individual, who has lymphoma, are engineered to express a chimeric antigen receptor (CAR) that specifically binds to an antigen present on lymphoma cells. The CAR localizes the engineered phagocytes to sites where lymphoma cells are present. In some embodiments, phagocytic activity of the phagocytes is enhanced by further engineering the phagocytes to express a hyperactive Rac GTPase.

公开(公告)号：WO2023076691A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/048465

申请日：2022-10-31

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： GARUDADRI, Harinath ,  SOKOLOVA, Alice ,  HARRIS, Frederic

IPC: H04W88/06

Abstract: In accordance with a method for performing frequency subchannelization, a digital signal is received at an original sampling rate. A plurality of multirate frequency channels is produced by dividing the digital signal into an integer number of multirate frequency channels such that a sampling rate of each of the multirate frequency channels is proportional to a center frequency of the frequency channel. After performing signal processing on each of the multirate frequency channels, the multirate frequency channels are reverted to the original sampling rate.

公开(公告)号：WO2023076600A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/048225

申请日：2022-10-28

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： ZARRINPAR, Ali ,  HO, Chih-Ming ,  BRUNER, Julia ,  DUARTE, Sergio ,  WARREN, Curtis ,  LEWIS, Duncan ,  PADMANABHAN, Neeraj ,  AL-BAHOU, Raja

IPC: A61K31/573 ,  A61K31/436 ,  A61P37/06 ,  G16B40/00 ,  G16H20/10 ,  C12Q1/6844

Abstract: The art does not provide systematic and reproducible methods to personalize dosing of multiple immunosuppressive medications after transplantation. This invention provides a method to systematize multi -drug immunosuppression management in tissue and organ transplantation using an artificial intelligence-based complex systems approach. In embodiments of this invention, immunosuppression drug dose, blood drug concentrations, donor-derived fraction of cell free DNA (dd-cfDNA%), and aspartate aminotransferase are used to indicate allograft status or a proxy for allograft status, to generate a phenotypic response surface to produce individual treatment modalities and dosages using empirically determined unique coefficients. This surface is used to calculate appropriate immunosuppression drug doses associated with the desired outcome for that patient. Embodiments of this disclosure are directed to identifying optimized combinations of inputs for the complex system of the immunosuppressed transplant patient in order to avoid transplant rejection while avoiding unnecessary toxicity and maintaining a robust enough immune response to fight infection.

公开(公告)号：WO2023069424A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/047005

申请日：2022-10-18

Applicant: CZ BIOHUB SF, LLC ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： ABATE, Adam ,  VASUDEVAN, Harish ,  DEMAREE, Benjamin ,  DELLEY, Cyrille, L.

IPC: C12Q1/6869 ,  C12Q1/6806 ,  C12N15/10 ,  G16B25/10

Abstract: The present disclosure provides materials and methods for contemporaneously analyzing genotype and phenotype from frozen specimens, the present disclosure can be extended to any biologic context where obtaining nucleic acid and protein information from single nuclei is valuable. As used herein, the method is termed nuclear DAb-seq (nDAb-seq).