发明申请
WO2008151112A1 USE OF 3-ALKANOYLOXYMETHOXYCARBONYL NITROXIDE ESTERS AS OXIMETRY PROBES FOR MEASUREMENT OF OXYGEN STATUS IN TISSUES
审中-公开
作为用于测量组织中氧气状态的OXIMETRY探针的3-烷基氧乙氧基甲基氧化亚硝酸酯的使用
- 专利标题： USE OF 3-ALKANOYLOXYMETHOXYCARBONYL NITROXIDE ESTERS AS OXIMETRY PROBES FOR MEASUREMENT OF OXYGEN STATUS IN TISSUES
- 专利标题（中）： 作为用于测量组织中氧气状态的OXIMETRY探针的3-烷基氧乙氧基甲基氧化亚硝酸酯的使用
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申请号： PCT/US2008/065495申请日： 2008-06-02
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公开(公告)号： WO2008151112A1公开(公告)日： 2008-12-11
- 发明人: KAO, Joseph, P.Y. , ROSEN, Gerarld, M. , LIU, Ke-Jian
- 申请人： UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE , UNIVERSITY OF MARYLAND AT BALTIMORE , UNIVERSITY OF NEW MEXICO , KAO, Joseph, P.Y. , ROSEN, Gerarld, M. , LIU, Ke-Jian
- 申请人地址： 701 E. Pratt Street, Suite 200 Baltimore, MD 21202 US
- 专利权人： UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE,UNIVERSITY OF MARYLAND AT BALTIMORE,UNIVERSITY OF NEW MEXICO,KAO, Joseph, P.Y.,ROSEN, Gerarld, M.,LIU, Ke-Jian
- 当前专利权人： UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE,UNIVERSITY OF MARYLAND AT BALTIMORE,UNIVERSITY OF NEW MEXICO,KAO, Joseph, P.Y.,ROSEN, Gerarld, M.,LIU, Ke-Jian
- 当前专利权人地址： 701 E. Pratt Street, Suite 200 Baltimore, MD 21202 US
- 代理机构： FUIERER, Marianne et al.
- 优先权： US60/932,443 20070601
- 主分类号： A61K49/10
- IPC分类号： A61K49/10 ; A61P1/00
摘要：
The present invention provides for lipophilic, labile alkanoyloxymethyl esters of nitroxides that cross the blood-brain barrier, and after hydrolysis with esterases therein, the corresponding anionic nitroxides are intracellularly entrapped at levels sufficient to permit O 2 measurements by electron paramagnetic resonance spectroscopy.
