公开(公告)号：WO2008151112A1

公开(公告)日：2008-12-11

申请号：PCT/US2008/065495

申请日：2008-06-02

申请人： UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE ,  UNIVERSITY OF MARYLAND AT BALTIMORE ,  UNIVERSITY OF NEW MEXICO ,  KAO, Joseph, P.Y. ,  ROSEN, Gerarld, M. ,  LIU, Ke-Jian

发明人： KAO, Joseph, P.Y. ,  ROSEN, Gerarld, M. ,  LIU, Ke-Jian

IPC分类号： A61K49/10 ,  A61P1/00

CPC分类号： A61K49/20 ,  A61K49/0004

摘要： The present invention provides for lipophilic, labile alkanoyloxymethyl esters of nitroxides that cross the blood-brain barrier, and after hydrolysis with esterases therein, the corresponding anionic nitroxides are intracellularly entrapped at levels sufficient to permit O 2 measurements by electron paramagnetic resonance spectroscopy.

摘要翻译： 本发明提供了穿过血脑屏障的硝基氧的亲脂性，不稳定的烷酰氧基甲基酯，并且在其中酯酶水解后，相应的阴离子氮氧化物以足以允许通过电子顺磁共振光谱法进行O 2测量的水平被细胞内包埋。

公开(公告)号：WO2003095449A1

公开(公告)日：2003-11-20

申请号：PCT/US2003/013849

申请日：2003-05-05

申请人： SCIENCE AND TECHNOLOGY CORPORATION @ UNIVERSITY OF NEW MEXICO ,  REGENTS OF THE UNIVERSITY OF MINNESOTA ,  LARSON, Richard, S. ,  WAGNER, Carston

发明人： LARSON, Richard, S. ,  WAGNER, Carston

IPC分类号： C07D405/14

CPC分类号： C07D401/12 ,  B01F13/0059 ,  B01F13/0093 ,  B01F13/0096 ,  B01F15/0201 ,  B01F15/024 ,  C07D233/76 ,  C07D405/12

摘要： The present invention provides a compound and a method of making a compound according to the following formula: where R 1 is an alkyl group having 1 to 12 carbons; R 2 is a urea group; R 3 is an active group, such as fluorescein, a toxin, radiolabel or drug; and R 4 , R 5 and R 6 are each independently a halide group.

摘要翻译： 本发明提供一种化合物及其制备方法，其中R1为具有1至12个碳原子的烷基; R2是尿素基团; R3是活性基团，例如荧光素，毒素，放射性标记物或药物; R 4，R 5和R 6各自独立地为卤素基团。

公开(公告)号：WO2003037491A2

公开(公告)日：2003-05-08

申请号：PCT/US2002/034244

申请日：2002-10-25

申请人： SCIENCE AND TECHNOLOGY CORPORATION @ UNIVERSITY OF NEW MEXICO ,  SKLAR, Larry ,  BURANDA, Tione ,  EDWARDS, Bruce ,  GALLEGOS, Carlos ,  JACKSON, W., Coyt ,  KUCKUCK, Frederick ,  LOPEZ, Gabriel ,  MAMMOLI, Andrea

发明人： SKLAR, Larry ,  BURANDA, Tione ,  EDWARDS, Bruce ,  GALLEGOS, Carlos ,  JACKSON, W., Coyt ,  KUCKUCK, Frederick ,  LOPEZ, Gabriel ,  MAMMOLI, Andrea

IPC分类号： B01F

CPC分类号： G01N35/085 ,  B01F13/0071 ,  B01L3/0293 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/0099 ,  G01N35/08 ,  G01N35/1011 ,  G01N2015/1413 ,  G01N2015/149 ,  G01N2035/00514 ,  G01N2035/00544

摘要： A mixing apparatus is provided comprising: first driving means for driving a plurality of reagent samples from a plurality of respective source wells into a first fluid flow stream; second driving means for introducing a separation gas between each of the plurality of reagent sample in the first fluid flow stream; means for driving a second fluid flow stream comprising a plurality of particles; a junction device comprising: a first inlet port for receiving the first fluid flow stream; a second inlet port for receiving the second fluid flow stream; a reaction zone for forcing mixing between the first fluid flow stream and the second fluid flow stream to thereby form a reaction product stream; and an outlet port for allowing the reaction product stream to exit the junction device; a reaction zone where the plurality of reagent samples and the plurality of particles mix to form a plurality of reaction products, the reaction zone communicating with the outlet port; reaction product driving means for driving the reaction product stream through the reaction zone; and means for selectively analyzing the reaction product stream for the reaction products. A method for mixing materials is also provided comprising: driving a first fluid flow stream comprising a plurality of reagent samples separated by gas bubbles through a second inlet port of a junction device; driving a second fluid flow stream comprising particles through a first inlet port of the junction device; mixing the first fluid stream and the second fluid stream in a reaction zone in the junction device to form a reaction product stream; and driving the reaction product stream through an outlet port of the junction device.

摘要翻译： 提供了一种混合设备，包括：第一驱动装置，用于将多个试剂样品从多个相应的源阱驱动到第一流体流中; 第二驱动装置，用于在所述第一流体流中的所述多个试剂样品中的每一个之间引入分离气体; 用于驱动包括多个颗粒的第二流体流动流的装置; 连接装置，包括：用于接收第一流体流动的第一入口; 用于接收第二流体流的第二入口; 用于迫使所述第一流体流和所述第二流体流之间的混合从而形成反应产物流的反应区; 以及用于允许反应产物流离开接合装置的出口; 反应区，其中所述多个试剂样品和所述多个颗粒混合以形成多个反应产物，所述反应区与所述出口连通; 用于驱动反应产物流通过反应区的反应产物驱动装置; 以及用于选择性分析反应产物的反应产物流的装置。 还提供了一种用于混合材料的方法，包括：驱动包含通过气泡隔开的多个试剂样品的第一流体流，通过连接装置的第二入口; 通过所述连接装置的第一入口驱动包含颗粒的第二流体流; 将所述第一流体流和所述第二流体流在所述连接装置中的反应区中混合以形成反应产物流; 并且通过连接装置的出口驱动反应产物流。

公开(公告)号：WO1996024821A1

公开(公告)日：1996-08-15

申请号：PCT/US1996001601

申请日：1996-02-06

申请人： UNIVERSITY OF NEW MEXICO

发明人： UNIVERSITY OF NEW MEXICO ,  DIELS, Jean-Claude, M. ,  PULASKI, Paul, D.

IPC分类号： G01C19/68

CPC分类号： H01S5/1071 ,  G01C19/66 ,  H01S3/06 ,  H01S3/083 ,  H01S5/3428

摘要： A laser gyroscope (30) comprising two ninety degree turning prisms (20, 22) optically connected. A non-reciprocal gain layer structure (24) is grown on the hypotenuse face of one prism (22).

摘要翻译： 激光陀螺仪（30）包括光学连接的两个九十度旋转棱镜（20,22）。 在一个棱镜（22）的斜边上生长非互易增益层结构（24）。

公开(公告)号：WO1994015387A1

公开(公告)日：1994-07-07

申请号：PCT/US1993012731

申请日：1993-12-22

申请人： UNIVERSITY OF NEW MEXICO

发明人： UNIVERSITY OF NEW MEXICO ,  YAN, Chi ,  REDDY, Kalidev'Apura, P., J. ,  JAIN, Ravinder, K. ,  McINERNEY, John, G.

IPC分类号： H01S03/098

CPC分类号： H01S5/06216 ,  H01S5/06223 ,  H01S5/0658

摘要： Filtered regenerative feedback is used to modulate a laser or other source of electromagnetic radiation to generate optical pulses whose amplitudes and repetition rates are continuously tunable. The technique involves converting, by means of a photodetector (9), a portion of the radiation produced by a modulatable electromagnetic radiation source (1, 7) into a control signal, filtering the control signal through a bandpass filter (3, 10), and modulating the modulatable radiation source with the filtered control signal to produce pulses. This technique is in principle applicable to any source of electromagnetic radiation and is especially effective for semiconductor diode lasers.

摘要翻译： 过滤的再生反馈用于调制激光或其他电磁辐射源，以产生振幅和重复率连续可调的光脉冲。 该技术涉及通过光电检测器（9）将由可调制电磁辐射源（1,7）产生的辐射的一部分转换成控制信号，通过带通滤波器（3,10）对控制信号进行滤波， 并用滤波的控制信号调制可调制的辐射源，以产生脉冲。 该技术原则上适用于任何电磁辐射源，对半导体二极管激光器尤为有效。

公开(公告)号：WO1992019264A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003675

申请日：1992-05-01

申请人： UNIVERSITY OF NEW MEXICO

发明人： UNIVERSITY OF NEW MEXICO ,  BORN, Jerry, L. ,  ESHIMA, Dennis ,  MANN, Paul, L. ,  MATWIYOFF, Nicholas, A. ,  KROH, Frank, O.

IPC分类号： A61K39/02

CPC分类号： A61K49/085 ,  A61K47/6415 ,  A61K49/10 ,  A61K49/14 ,  A61K51/0497 ,  A61K51/08 ,  A61K51/081 ,  A61K2121/00 ,  A61K2123/00

摘要： Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body. Biomodulators can be also administered together with an agent such as a drug or an imaging agent (specific or non-specific) structurally modified to take advantage of perturbations of cell oligosaccharide displays caused by biomodulators, to enhance images of a host, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators condition tissue to enhance or otherwise modify up-take of the drug or structurally modified agent.

摘要翻译： 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂还可以调节组织以增强非特异性成像剂的吸收。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。 生物调节剂还可与诸如药物或成像剂（特异性或非特异性）的试剂一起施用，其结构修饰以利用由生物调节剂引起的细胞寡糖显示的扰动，以增强宿主的图像，例如NMR- ，X射线或放射线图像，优选通过增加异常组织信号强度。 生物调节剂调节组织以增强或以其它方式改变药物或结构改性剂的摄取。

公开(公告)号：WO1992019240A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003672

申请日：1992-05-01

申请人： UNIVERSITY OF NEW MEXICO

发明人： UNIVERSITY OF NEW MEXICO ,  MANN, Paul, L. ,  MASH, Eugene ,  SCALLEN, Terence, J.

IPC分类号： A61K31/44

CPC分类号： A61K31/445 ,  A61K31/19 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4164 ,  A61K2039/55511 ,  A61K2039/55594 ,  C12N2501/999 ,  Y10S514/883

摘要： Biomodulators, which regulate cellular differentiation and proliferation, as well as methods of use thereof, e.g., for treating various conditions, e.g., cancer, senescence, immunological disorders and vascular disease; for stimulating normal tissue architecture after injury; for vaccination; for stimulating the production of biologically important molecules by cells or organs in culture; for maintaining organs or tissues outside of a body after removal from the body and prior to transplantation; and for producing vascular grafts for transplantation; are provided.

摘要翻译： 调节细胞分化和增殖的生物调节剂，以及其使用方法，例如用于治疗各种病症，例如癌症，衰老，免疫学疾病和血管疾病; 用于刺激损伤后的正常组织结构; 接种疫苗 用于刺激培养物中细胞或器官生物重要分子的生成; 用于在身体移除后和移植前将器官或组织保持在身体外部; 并用于生产用于移植的血管移植物; 被提供。

公开(公告)号：WO1991013590A1

公开(公告)日：1991-09-19

申请号：PCT/US1990001044

申请日：1990-03-06

申请人： UNIVERSITY OF NEW MEXICO ,  CUSHMAN, Robert, M.

发明人： UNIVERSITY OF NEW MEXICO ,  KIRSCH, Wolff, Mayer ,  ZHU, Yong, Hua

IPC分类号： A61B17/28

CPC分类号： A61B17/30 ,  A61B17/11

摘要： A forceps for holding and everting vessels in an anastomosis procedure includes three cooperating jaws (32, 34, 36) mounted at the ends of respective relatively movable legs (10, 12, 14). The legs (10, 12, 14) can be independently manipulated in order to secure and evert first one vessel, then another in apposition to the first, so that clips or sutures can be applied to complete the anastomosis.

公开(公告)号：WO1989005605A1

公开(公告)日：1989-06-29

申请号：PCT/US1988004533

申请日：1988-12-19

申请人： UNIVERSITY OF NEW MEXICO

发明人： UNIVERSITY OF NEW MEXICO ,  WILKINS, Ebtisam, S.

IPC分类号： A61B05/00

CPC分类号： G01N27/3335

摘要： An improved membrane electrode (11) for measuring the concentration of a non-ionic species in an essentially aqueous medium comprising: an electrically conductive substrate (17); a first coating (13) surrounding said substrate (17) composed of a mixture of polymeric material, an anion exchange material, and a water-insoluble alkaline earth metal salt of said non-ionic species, and a hydrogel coating (15) of material surrounding said first coating (13) having a positive charge of sufficient potential to prevent leaching of the substantial amounts of the alkaline earth metal component of said salt.

公开(公告)号：WO2017001466A1

公开(公告)日：2017-01-05

申请号：PCT/EP2016/065125

申请日：2016-06-29

申请人： INSTITUT MINES-TELECOM ,  UNIVERSITY OF NEW MEXICO

发明人： OSINSKI, Marek ,  GRILLOT, Frédéric

IPC分类号： H01S5/026 ,  H01S5/10 ,  H01S5/14 ,  H01S5/02 ,  H01S5/022 ,  H01S5/06

CPC分类号： H01S5/1028 ,  H01S5/021 ,  H01S5/0215 ,  H01S5/0224 ,  H01S5/02248 ,  H01S5/0228 ,  H01S5/0612 ,  H01S5/068 ,  H01S5/101 ,  H01S5/1032 ,  H01S5/125 ,  H01S5/142 ,  H01S5/34313 ,  H01S5/3434

摘要： The invention concerns a wavelength tunable semiconductor laser comprising a laser gain section (510) optically coupled to an underlying optical waveguide (520). According to an embodiment of the invention, a first and a second passive microring resonators (530, 560) having a whistle geometry, are arranged on both sides of the laser gain section and evanescently coupled with the optical waveguide (520). Highly reflective broadband mirrors (541, 571) are provided at the free ends of optical waveguide branches (240, 270) tangentially connected to the microring resonators. The first and second passive microrings resonators provide an optical feedback to the laser gain section and allow to select the desired wavelength. The laser structure can be implemented according to a III-V/Si technology.

摘要翻译： 本发明涉及一种包括光学耦合到下面的光波导（520）的激光增益部分（510）的波长可调谐半导体激光器。 根据本发明的实施例，具有口哨几何形状的第一和第二无源微环谐振器（530,560）被布置在激光增益部分的两侧上，并与光波导（520）瞬时耦合。 在与微环谐振器切向连接的光波导分支（240,270）的自由端处提供高反射宽带镜（541,571）。 第一和第二无源微环谐振器向激光增益部分提供光学反馈并允许选择所需的波长。 激光器结构可以根据III-V / Si技术实现。