Invention Application
- Patent Title: (1,4-DIAZA-BICYCLO[3.2.2]NON-6-EN-4-YL)-HETEROCYCLYL-METHANONE LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, USEFUL FOR THE TREATMENT OF DISEASE
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Application No.: PCT/US2008/080743Application Date: 2008-10-22
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Publication No.: WO2009055437A3Publication Date: 2009-04-30
- Inventor: HERBERT, Brian , SCHUMACHER, Richard , DAI, Guangxiu , XIE, Wenge
- Applicant: MEMORY PHARMACEUTICALS CORPORATION , HERBERT, Brian , SCHUMACHER, Richard , DAI, Guangxiu , XIE, Wenge
- Applicant Address: 100 Philips Parkway Montvale, New Jersey 07645 US
- Assignee: MEMORY PHARMACEUTICALS CORPORATION,HERBERT, Brian,SCHUMACHER, Richard,DAI, Guangxiu,XIE, Wenge
- Current Assignee: MEMORY PHARMACEUTICALS CORPORATION,HERBERT, Brian,SCHUMACHER, Richard,DAI, Guangxiu,XIE, Wenge
- Current Assignee Address: 100 Philips Parkway Montvale, New Jersey 07645 US
- Agency: HEANEY, Brion P. et al.
- Priority: US60/981,643 20071022; US61/050,366 20080505
- Main IPC: C07D453/00
- IPC: C07D453/00 ; C07D307/78 ; A61K31/4045 ; A61K31/439
Abstract:
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds, which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof. The novel compounds include compounds of formula I: (I) wherein X, R1, and R2 are as herein defined.
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