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公开(公告)号：WO2011068506A1
公开(公告)日：2011-06-09
申请号：PCT/US2009/066322
申请日：2009-12-02
Inventor： ROUSSEAU, Letha , SCHUMACHER, Richard
CPC classification number: G01R1/06772 , G01R31/2822
Abstract: Apparatus are provided for use in testing circuit boards. A signal sensing device includes one or more probes. Each probe includes a length of rigid coaxial conductor configured to define a sensing pin at one end. A circuit board defines a number of through vias lined in metal and configured to receive the sensing pin of a corresponding probe. The signal sensing device also includes a ground pin. Electrical pathways extending away from adjacent pairs of the through vias can be tested for electrical impedance and other signal propagating characteristics by way of the signal sensing device.
Abstract translation: 提供了用于测试电路板的设备。 信号感测装置包括一个或多个探针。 每个探头包括一长度的刚性同轴导体，其被配置为在一端限定感测针。 电路板定义了金属内衬的多个通孔，并配置为接收相应探针的感测针。 信号感测装置还包括接地引脚。 可以通过信号传感装置测试从相邻的通孔对延伸的电路，以获得电阻抗和其他信号传播特性。
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公开(公告)号：WO2010129704A3
公开(公告)日：2011-02-03
申请号：PCT/US2010033770
申请日：2010-05-05
Applicant: PRESSURE BIOSCIENCES INC , TING EDMUND , LAZAREV ALEXANDER , SCHUMACHER RICHARD , DUSSAULT CHARLES , FRITZSCHE WAYNE
Inventor： TING EDMUND , LAZAREV ALEXANDER , SCHUMACHER RICHARD , DUSSAULT CHARLES , FRITZSCHE WAYNE
IPC: G01N1/28
CPC classification number: G01N1/286 , B01L3/505 , B01L3/5082 , B01L9/06 , B01L2300/14
Abstract: Sample processing devices having collapsible, flexible bodies are disclosed. The flexible microtube sampling devices are utilizable in pressure mediated, pressure cycling procedures. Externally applied pressure on the flexible microtube sample processing devices allow buckling thereof and transfer of the applied pressure to the sample contained therein.
Abstract translation: 公开了具有可折叠，柔性体的样品处理装置。 柔性微管采样装置可用于压力介导的压力循环程序。 柔性微管样品处理装置上的外部施加的压力允许其弯曲并将施加的压力转移到其中所含的样品。
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公开(公告)号：WO2010129704A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/033770
申请日：2010-05-05
Applicant: PRESSURE BIOSCIENCES INC. , TING, Edmund , LAZAREV, Alexander , SCHUMACHER, Richard , DUSSAULT, Charles , FRITZSCHE, Wayne
Inventor： TING, Edmund , LAZAREV, Alexander , SCHUMACHER, Richard , DUSSAULT, Charles , FRITZSCHE, Wayne
IPC: G01N1/28
CPC classification number: G01N1/286 , B01L3/505 , B01L3/5082 , B01L9/06 , B01L2300/14
Abstract: Sample processing devices having collapsible, flexible bodies are disclosed. The flexible microtube sampling devices are utilizable in pressure mediated, pressure cycling procedures. Externally applied pressure on the flexible microtube sample processing devices allow buckling thereof and transfer of the applied pressure to the sample contained therein.
Abstract translation: 公开了具有可折叠，柔性体的样品处理装置。 柔性微管采样装置可用于压力介导的压力循环程序。 柔性微管样品处理装置上的外部施加的压力允许其弯曲并将施加的压力转移到其中所含的样品。
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4.发明申请SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION 审中-公开由温德勒控制的压缩旋转引起的机械破坏的SHREDDER
公开(公告)号：WO2010033740A3
公开(公告)日：2010-05-06
申请号：PCT/US2009057370
申请日：2009-09-17
Applicant: PRESSURE BIOSCIENCES INC , TING EDMUND Y , LAZAREV ALEXANDER , GROSS VERA , DUSSAULT CHARLES , LI CHUNQIN , LAWRENCE NATHAN , SCHUMACHER RICHARD T
Inventor： TING EDMUND Y , LAZAREV ALEXANDER , GROSS VERA , DUSSAULT CHARLES , LI CHUNQIN , LAWRENCE NATHAN , SCHUMACHER RICHARD T
IPC: G01N1/28
CPC classification number: G01N1/286 , C12M35/04 , G01N2001/2866
Abstract: The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
Abstract translation: 本发明的系统和技术还可协同利用机械破碎过程，使用高流体静力学压力提取（例如压力循环提取技术）以实现难以提取样品成分的高产率而不产生高剪切应力或高温。
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公开(公告)号：WO2009055437A3
公开(公告)日：2009-04-30
申请号：PCT/US2008/080743
申请日：2008-10-22
Applicant: MEMORY PHARMACEUTICALS CORPORATION , HERBERT, Brian , SCHUMACHER, Richard , DAI, Guangxiu , XIE, Wenge
Inventor： HERBERT, Brian , SCHUMACHER, Richard , DAI, Guangxiu , XIE, Wenge
IPC: C07D453/00 , C07D307/78 , A61K31/4045 , A61K31/439
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds, which act as ligands for the a7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof. The novel compounds include compounds of formula I: (I) wherein X, R1, and R2 are as herein defined.
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Patent Agency Ranking
公开(公告)号：WO2008112761A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056658
申请日：2008-03-12
Applicant: CONAGRA FOODS RDM, INC. , DIERKING, Mark , SCHUMACHER, Richard , HOPKINS, Jerry
Inventor： DIERKING, Mark , SCHUMACHER, Richard , HOPKINS, Jerry
Abstract: Methods for producing a partially hydrated bean paste are disclosed. The methods include inputting a quantity of uncooked whole beans or split beans into an extruder comprising an inlet, one or more temperature zones in series downstream of the inlet, and a die downstream of the one or more temperature zones; rotating a screw assembly of the extruder to extrude the beans and force the beans through the one or more temperature zones, wherein a quantity of steam and a quantity of water is added to the beans as the beans are forced through each temperature zone; and forcing the beans exiting the final temperature zone of said one or more temperature zones in series through the die to produce a bean paste. The partially hydrated bean paste produced by the methods of the disclosure comprises a water content of at least about 45% by weight. The partially hydrated bean paste can be further processed into partially hydrated bean products, such as refried beans.
Abstract translation: 公开了生产部分水合豆酱的方法。 所述方法包括将一批未煮熟的全豆或分裂豆输入到挤出机中，所述挤出机包括入口，在入口下游的串联的一个或多个温度区域和在所述一个或多个温度区域下游的模具; 旋转挤出机的螺杆组件以挤出豆子并迫使豆子通过一个或多个温度区域，其中当豆被强制通过每个温度区域时，将一定量的蒸汽和一定量的水加入豆中; 并且迫使通过模具串联的所述一个或多个温度区域的最终温度区域离开出来的豆以产生豆浆。 通过本公开的方法制备的部分水合的豆酱包含至少约45重量％的水含量。 部分水合的豆酱可以进一步加工成部分水合的豆制品，例如重烧豆。
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7.发明申请1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF 审中-公开1 H-INDAZOLES，BENZOTHIAZOLES，1,2-BENZOISOXAZOLES，1,2-BENZOISOTHIAZOLES和CHROMONES及其制备及其用途
公开(公告)号：WO2007056582A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/043818
申请日：2006-11-09
Applicant: MEMORY PHARMACEUTICALS CORPORATION , SCHUMACHER, Richard A. , MA, Jianguo , HERBERT, Brian , DANCA, Mihaela Diana , XIE, Wenge , NGUYEN, Truc Minh , TEHIM, Ashok
Inventor： SCHUMACHER, Richard A. , MA, Jianguo , HERBERT, Brian , DANCA, Mihaela Diana , XIE, Wenge , NGUYEN, Truc Minh , TEHIM, Ashok
IPC: C07D487/08 , A61K31/551 , A61P25/28
CPC classification number: C07D471/08 , C07D487/08
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of -disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化，以及治疗与缺陷或功能异常的烟碱乙酰胆碱受体（特别是脑）有关的疾病病症。 此外，本发明涉及作为a7 nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这种化合物的方法，含有这些化合物的组合物及其使用方法。
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8.发明申请1H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF 审中-公开1H-INDAZOLES，BENZOTHIAZOLES，1,2-BENZOISOXAZOLES，1,2-BENZOISOTHIAZOLES AND AND CHROMONES AND Preparation and Preparation and
公开(公告)号：WO2005111038A3
公开(公告)日：2006-08-31
申请号：PCT/US2005015937
申请日：2005-05-06
Applicant: MEMORY PHARM CORP , XIE WENGE , HERBERT BRIAN , SCHUMACHER RICHARD A , MA JIANGUO , NGUYEN TRUC MINH , GAUSS CARLA MARIA , TEHIM ASHOK
Inventor： XIE WENGE , HERBERT BRIAN , SCHUMACHER RICHARD A , MA JIANGUO , NGUYEN TRUC MINH , GAUSS CARLA MARIA , TEHIM ASHOK
IPC: C07D471/08 , A61K31/4985 , A61K31/551 , A61P25/28 , C07D487/08
CPC classification number: C07D471/08 , C07D487/08
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the a7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）的配体领域，nAChR的活化以及与缺陷或功能不良的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状况的治疗。 此外，本发明涉及作为a7 nAChR亚型的配体的新化合物（吲唑和苯并噻唑），制备这种化合物的方法，含有这些化合物的组合物及其使用方法。
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公开(公告)号：WO2006069097A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/046256
申请日：2005-12-21
Applicant: MEMORY PHARMACEUTICALS CORPORATION , NGUYEN, Truc, Minh , XIE, Wenge , SCHUMACHER, Richard , HERBERT, Brian , TEHIM, Ashok
Inventor： NGUYEN, Truc, Minh , XIE, Wenge , SCHUMACHER, Richard , HERBERT, Brian , TEHIM, Ashok
IPC: C07D453/02 , A61K31/439 , A61P25/00
CPC classification number: C07D453/02
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nAChR）配体领域，nAChRs的激活以及治疗与烟碱乙酰胆碱受体缺陷或功能障碍相关的疾病状态，尤其是脑部。 此外，本发明涉及用作α7nAChR亚型的配体的新化合物，制备这些化合物的方法，含有这些化合物的组合物，以及它们的使用方法。
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10.发明申请INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF 审中-公开吲哚，1H-INDAZOLES，1,2-苄基氧杂环己烷，1,2-苯并唑烷，及其制备及用途
公开(公告)号：WO2006001894A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/013938
申请日：2005-04-22
Applicant: MEMORY PHARMACEUTICAL CORPORATION , HERBERT, Brian , GAUSS, Carla, Maria , XIE, Wenge , NGUYEN, Truc, Minh , MA, Jianguo , SCHUMACHER, Richard , TEHIM, Ashok
Inventor： HERBERT, Brian , GAUSS, Carla, Maria , XIE, Wenge , NGUYEN, Truc, Minh , MA, Jianguo , SCHUMACHER, Richard , TEHIM, Ashok
IPC: C07D451/04
CPC classification number: C07D451/04 , C07D451/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Abstract translation: 本发明一般涉及烟碱乙酰胆碱受体（nACh受体）的配体领域，nACh受体的活化以及与缺陷或功能异常的烟碱乙酰胆碱受体，特别是脑的疾病相关的疾病状态的治疗。 此外，本发明涉及作为a7 nACh受体亚型的配体的新化合物（吲唑和苯并噻唑），制备这些化合物的方法，含有这些化合物的组合物及其使用方法。
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