Invention Application
- Patent Title: NOVEL COMPOUNDS, USE AND PREPARATION THEREOF
- Patent Title (中): 新化合物，其使用和制备
-
Application No.: PCT/EP2009/050931Application Date: 2009-01-28
-
Publication No.: WO2009095399A2Publication Date: 2009-08-06
- Inventor: JENMALM JENSEN, Annika , LEHMANN, Fredrik , NILSSON, Björn, M. , NORDLING, Erik , PARROW, Vendela
- Applicant: BIOVITRUM AB (publ) , JENMALM JENSEN, Annika , LEHMANN, Fredrik , NILSSON, Björn, M. , NORDLING, Erik , PARROW, Vendela
- Applicant Address: S-112 76 Stockholm SE
- Assignee: BIOVITRUM AB (publ),JENMALM JENSEN, Annika,LEHMANN, Fredrik,NILSSON, Björn, M.,NORDLING, Erik,PARROW, Vendela
- Current Assignee: BIOVITRUM AB (publ),JENMALM JENSEN, Annika,LEHMANN, Fredrik,NILSSON, Björn, M.,NORDLING, Erik,PARROW, Vendela
- Current Assignee Address: S-112 76 Stockholm SE
- Agency: DANIELSSON, Helena
- Priority: SE0800250-3 20080201; US61/123,039 20080404; SE0801185-0 20080521
- Main IPC: C07D241/20
- IPC: C07D241/20 ; C07D401/04 ; C07D401/14 ; C07D403/12 ; C07D417/14 ; A61K31/497 ; A61K31/4965 ; A61K31/5415 ; A61P35/00 ; A61P17/00 ; C07D407/14 ; C07D409/14
Abstract:
The present invention relates to compounds of the general formula (I) wherein R 1 , R 2 and R 3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis.
Information query
