Invention Application
- Patent Title: USE OF SIRNA TO ACHIEVE DOWN REGULATION OF AN ENDOGENOUS GENE IN COMBINATION WITH THE USE OF A SENSE CONSTRUCT TO ACHIEVE EXPRESSION OF A DESIRED POLYNUCLEOTIDE
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Application No.: PCT/US2009/036583Application Date: 2009-03-09
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Publication No.: WO2009114487A9Publication Date: 2009-09-17
- Inventor: DONDERO, Richard S. , TAYLOR, Catherine A.
- Applicant: SENESCO TECHNOLOGIES, INC. , DONDERO, Richard S. , THOMPSON, John E. , TAYLOR, Catherine A.
- Applicant Address: 303 George Street Suite 420 New Brunswick, NJ 08901 US
- Assignee: SENESCO TECHNOLOGIES, INC.,DONDERO, Richard S.,THOMPSON, John E.,TAYLOR, Catherine A.
- Current Assignee: SENESCO TECHNOLOGIES, INC.,DONDERO, Richard S.,THOMPSON, John E.,TAYLOR, Catherine A.
- Current Assignee Address: 303 George Street Suite 420 New Brunswick, NJ 08901 US
- Agency: LAVENUE, Teresa A. et al.
- Priority: US61/034,830 20080308
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/02 ; C12N15/63 ; A61K48/00
Abstract:
The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.
Information query
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