发明申请
- 专利标题： PROCESS FOR THE PREPARATION OF DONEPEZIL HYDROCHLORIDE
- 专利标题（中）： 二苯醚氯化氢的制备方法
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申请号： PCT/GB2009000776申请日： 2009-03-24
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公开(公告)号： WO2009118516A8公开(公告)日： 2010-10-21
- 发明人: RAO DHARMARAJ RAMACHANDRA , KANKAN RAJENDRA NARAYANRAO , PATHI SRINIVAS LAXMINARAYAN
- 申请人： CIPLA LTD , RAO DHARMARAJ RAMACHANDRA , KANKAN RAJENDRA NARAYANRAO , PATHI SRINIVAS LAXMINARAYAN , CURTIS PHILIP ANTHONY
- 专利权人： CIPLA LTD,RAO DHARMARAJ RAMACHANDRA,KANKAN RAJENDRA NARAYANRAO,PATHI SRINIVAS LAXMINARAYAN,CURTIS PHILIP ANTHONY
- 当前专利权人： CIPLA LTD,RAO DHARMARAJ RAMACHANDRA,KANKAN RAJENDRA NARAYANRAO,PATHI SRINIVAS LAXMINARAYAN,CURTIS PHILIP ANTHONY
- 优先权： IN636MU2008 2008-03-25
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61P25/28 ; C07D213/20 ; C07D295/03
摘要：
The present invention provides a process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2- yl)methylene]pyridonium halide of formula (II), wherein X is bromide or chloride, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting the donepezil to the salt thereof.
IPC分类:
