Invention Application
- Patent Title: INHIBITORS OF JNK
- Patent Title (中): JNK的抑制剂
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Application No.: PCT/EP2009/055443Application Date: 2009-05-06
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Publication No.: WO2009138340A1Publication Date: 2009-11-19
- Inventor: ARZENO, Humberto Bartolome , DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HAN, Xiaochun , HOGG, Joan Heather , JAHANGIR, Alam , PALMER, Wylie Solang , REUTER, Deborah Carol , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra , WU, Shao-Yong
- Applicant: F. HOFFMANN-LA ROCHE AG , ARZENO, Humberto Bartolome , DUNN, James Patrick , GOLDSTEIN, David Michael , GONG, Leyi , HAN, Xiaochun , HOGG, Joan Heather , JAHANGIR, Alam , PALMER, Wylie Solang , REUTER, Deborah Carol , SILVA, Tania , TIVITMAHAISOON, Parcharee , TREJO-MARTIN, Teresa Alejandra , WU, Shao-Yong
- Applicant Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Assignee: F. HOFFMANN-LA ROCHE AG,ARZENO, Humberto Bartolome,DUNN, James Patrick,GOLDSTEIN, David Michael,GONG, Leyi,HAN, Xiaochun,HOGG, Joan Heather,JAHANGIR, Alam,PALMER, Wylie Solang,REUTER, Deborah Carol,SILVA, Tania,TIVITMAHAISOON, Parcharee,TREJO-MARTIN, Teresa Alejandra,WU, Shao-Yong
- Current Assignee: F. HOFFMANN-LA ROCHE AG,ARZENO, Humberto Bartolome,DUNN, James Patrick,GOLDSTEIN, David Michael,GONG, Leyi,HAN, Xiaochun,HOGG, Joan Heather,JAHANGIR, Alam,PALMER, Wylie Solang,REUTER, Deborah Carol,SILVA, Tania,TIVITMAHAISOON, Parcharee,TREJO-MARTIN, Teresa Alejandra,WU, Shao-Yong
- Current Assignee Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Agency: HEIROTH, Ulrike
- Priority: US61/053,896 20080516
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/506 ; A61P29/00
Abstract:
The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula (I), wherein m, n, p, q, Q, r, R 1 , R 2 , R 3 , X, X 1 , X 2 , X 3 , X 4 , X 5 , Y 1 , Y 2 , Z 1 , and Z 2 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
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