发明申请
WO2009153668A3 METHOD FOR PURIFYING 4-(NITROOXY)BUTYL(2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE
审中-公开
4-（硝基）丁基（2S）-2-（6-甲氧基-2-萘基）丙酸酯的方法
- 专利标题： METHOD FOR PURIFYING 4-(NITROOXY)BUTYL(2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE
- 专利标题（中）： 4-（硝基）丁基（2S）-2-（6-甲氧基-2-萘基）丙酸酯的方法
-
申请号： PCT/IB2009006382申请日： 2009-06-18
-
公开(公告)号： WO2009153668A3公开(公告)日： 2010-02-11
- 发明人: ALLEGRINI PIETRO , SCUBLA TIZIANO , TONIUTTI NICOLETTA , RIVOLTA ROMANO , DELAHAIQUE THIERRY
- 申请人： NICOX SA , ALLEGRINI PIETRO , SCUBLA TIZIANO , TONIUTTI NICOLETTA , RIVOLTA ROMANO , DELAHAIQUE THIERRY
- 专利权人： NICOX SA,ALLEGRINI PIETRO,SCUBLA TIZIANO,TONIUTTI NICOLETTA,RIVOLTA ROMANO,DELAHAIQUE THIERRY
- 当前专利权人： NICOX SA,ALLEGRINI PIETRO,SCUBLA TIZIANO,TONIUTTI NICOLETTA,RIVOLTA ROMANO,DELAHAIQUE THIERRY
- 优先权： ITRM20080325 2008-06-20
- 主分类号： C07C203/04
- IPC分类号： C07C203/04
摘要：
The present invention relates to a method for purifying naproxcinod comprising the steps of : a) dissolving or dispersing a mixture containing naproxcinod in an amount higher than 90% by weight in a solvent; b) cooling the solution or two phases dispersion under stirring to a temperature ranging from -20°C to 10°C c) optionally seeding the solution with crystals of naproxcinod d) stirring, by maintaining the temperature in the range from - 40°C to 10°C e) collecting the formed solid by maintaining the temperature under 15°C A further object of the invention is a crystalline form of naproxcinod.
