Invention Application
WO2009155055A2 METHODS OF EFFECTING WNT SIGNALING THROUGH DKK STRUCTURAL ANALYSIS
审中-公开
通过DKK结构分析实现WNT信号的方法
- Patent Title: METHODS OF EFFECTING WNT SIGNALING THROUGH DKK STRUCTURAL ANALYSIS
- Patent Title (中): 通过DKK结构分析实现WNT信号的方法
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Application No.: PCT/US2009/045485Application Date: 2009-05-28
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Publication No.: WO2009155055A2Publication Date: 2009-12-23
- Inventor: ZHENG, Jie
- Applicant: ENZO BIOCHEM, INC. , ZHENG, Jie
- Applicant Address: 527 Madison Avenue New York, NY 10022 US
- Assignee: ENZO BIOCHEM, INC.,ZHENG, Jie
- Current Assignee: ENZO BIOCHEM, INC.,ZHENG, Jie
- Current Assignee Address: 527 Madison Avenue New York, NY 10022 US
- Agency: SCHULMAN, Robert, M.
- Priority: US61/130,098 20080528; US12/454,758 20090522
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K14/00 ; C12N5/00 ; C12N5/08 ; G01N33/53 ; C12Q1/68 ; A61P35/00 ; A61P25/28 ; A61P19/08 ; A61P19/02
Abstract:
Compositions and methods related to Wnt signaling regulation by Dickkopf (Dkk) polypeptides and Wnt-related diseases are disclosed. For example, compounds that Kind a Dkk or LRP polypeptide are disclosed. Compounds that disrupt binding of a Dkk polypeptide to an LRP polypeptide are also disclosed. Methods for using the described compounds and compositions are also disclosed.
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