公开(公告)号：WO2023089616A1

公开(公告)日：2023-05-25

申请号：PCT/IL2022/051230

申请日：2022-11-17

申请人： IMAGINDAIRY LTD.

发明人： ABO, Arie ,  LAVY-ALPEROVITCH, Ariella

IPC分类号： A23L33/195 ,  A23L33/15 ,  A61K31/714 ,  A61K35/66 ,  A61K38/16 ,  C12N1/14 ,  C12N15/85

摘要： The present invention provides a composition comprising cobalamin and a mammalian transcobalamin (TC) polypeptide, heterologously expressed in a recombinant cell. Further provided are food compositions comprising the cobalamin bound to the recombinant TC polypeptide, as well as methods of producing thereof, such as producing a dairy-like food composition.

公开(公告)号：WO2023086929A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/079702

申请日：2022-11-11

申请人： SHATTUCK LABS, INC.

发明人： PANDITE, Arundathy ,  RANGWALA, Fatima ,  LAMPKIN, Thomas ,  SCHREIBER, Taylor ,  FROMM, George ,  DE SILVA, Suresh

IPC分类号： C07K19/00 ,  A61K38/16 ,  C07K14/70578

摘要： The present disclosure relates, in part, to compositions and methods, including chimeric proteins, that find use in the treatment of disease, such as immunotherapies for cancer.

公开(公告)号：WO2023083950A1

公开(公告)日：2023-05-19

申请号：PCT/EP2022/081443

申请日：2022-11-10

申请人： AICURIS GMBH & CO. KG

发明人： LISCHKA, Peter ,  BUSCHMANN, Helmut ,  BHATTACHARJEE, Sonakshi

IPC分类号： A61K35/76 ,  A61K38/16 ,  A61P31/12

摘要： The invention relates to the treatment of respiratory virus infections and to preparing subjects for such an infection by administering a parapoxvirus in combination with immunomodulators. This is to assist the immune system in combatting the respiratory virus and to thereby prevent or to ameliorate symptoms of a respiratory virus disease.

公开(公告)号：WO2023079036A1

公开(公告)日：2023-05-11

申请号：PCT/EP2022/080740

申请日：2022-11-03

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ DE ROUEN ,  TARGEDYS

发明人： FETISSOV, Serguei ,  NICOL, Marion ,  PICOLO, Clémentine ,  LAMBERT, Grégory

IPC分类号： A61K35/747 ,  A61K35/745 ,  A61P25/24 ,  A61P25/22 ,  A61K38/16

摘要： The present invention relates to a composition comprising a probiotic composition comprising a Lactobacillus salivarius strain, a Lactobacillus camelliae strain and a Bifidobacterium ruminantium strain. The invention further relates to its use in the treatment of oxytocin-related disorders.

公开(公告)号：WO2023070078A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/078494

申请日：2022-10-21

申请人： THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

发明人： GRAYSON, Mitchell ,  HUSSAIN, Syed-Rehan

IPC分类号： A61K38/16 ,  A61P11/00 ,  A61P31/12

摘要： A method of treating or decreasing the risk of developing a respiratory viral infection in a subject is described. The method includes administering a therapeutically effective amount of neuregulin to the subject. A method of decreasing the risk that a subject will develop post-viral airway disease by administering an effective amount of neuregulin to the subject is also described.

公开(公告)号：WO2023070029A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/078426

申请日：2022-10-20

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： STEPHANOPOULOS, Nicholas ,  XU, Yang ,  SULC, Petr ,  YAN, Hao ,  ZHENG, Rong

IPC分类号： A61K39/215 ,  A61K9/00 ,  A61P31/14 ,  A61P37/04 ,  C12N15/11 ,  A61K38/16 ,  A61K39/39 ,  B82Y5/00

摘要： The present disclosure relates to DNA nanocarriers and methods of use for stimulating an immune response in a host. In some embodiments, the DNA nanocarriers comprise SARS-CoV-2 surface glycoprotein.

公开(公告)号：WO2023063827A1

公开(公告)日：2023-04-20

申请号：PCT/NL2022/050588

申请日：2022-10-14

申请人： OMNICIN THERAPEUTICS B.V. ,  RIJKSUNIVERSITEIT GRONINGEN

发明人： CASILLO, Rubèn Cebriàn ,  XIA, Yushan ,  KUIPERS, Oscar Paul

IPC分类号： A61K31/29 ,  A61K33/245 ,  A61K31/165 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/65 ,  A61K31/7048 ,  A61K31/7052 ,  A61K38/14 ,  A61K38/16 ,  A61K45/06 ,  A61K9/00 ,  A61P11/00 ,  A61P31/04

摘要： The invention relates to a bismuth containing composition for use in prophylaxis or treatment of an infection by Pseudomonas (P.) aeruginosa. The invention further relates to the concomitant use of a bismuth containing compound and an antibiotic for use in prophylaxis or treatment of an infection by P. aeruginosa. The invention further relates to an inhalation 5 device comprising a bismuth containing compound, and optionally an antibiotic, in particular for use in the treatment of a P. aeruginosa lung infection.

公开(公告)号：WO2023059590A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/045615

申请日：2022-10-04

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： ZHOU, Zhenqi

IPC分类号： A61K38/16 ,  C07K14/47 ,  A61P3/00 ,  A61P21/00

摘要： The present disclosure relates to compositions and methods for treaty obesity-related diseases. In some aspects, methods are provided for increasing the expression and/or activity of Dj 1 protein in a subject in need thereof.

公开(公告)号：WO2023049810A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/076879

申请日：2022-09-22

申请人： HEALTH RESEARCH, INC.

发明人： GUDKOV, Andrei ,  BRACKETT, Craig

IPC分类号： A61K38/43 ,  A61K38/16 ,  A61K38/17 ,  C12N15/86 ,  G01N33/68

摘要： Provided are methods for therapy or prophylaxis of genotoxic stress. The methods include administering to an individual in need an effective amount of Matrix Metalloproteinase (MMP)-9. The individual in need may have or be at risk of developing Acute Radiation Syndrome (ARS), or may have received or is receiving chemotherapy, or has insufficient hematopoietic function. The present disclosure provides results from a mouse model of lethal ARS induced by TBI to demonstrate that neutrophils (N ) are essential mediators of the radiomitigative but not radioprotective abilities of entolimod, express functional TLR5 but undergo minimal transcriptional changes post-entolimod suggesting that N mitigate 30 ARS through a transcriptional-independent mechanism; and increase the number of active hematopoietic pluripotent precursors (HPPs) in bone marrow.

公开(公告)号：WO2023041435A1

公开(公告)日：2023-03-23

申请号：PCT/EP2022/075118

申请日：2022-09-09

申请人： SYNGULON S.A.

发明人： MARTIN, Anandi ,  GABANT, Philippe

IPC分类号： A61K38/16 ,  A61L2/00 ,  A61P31/00

摘要： Described herein are bacteriocin peptides, peptidomimetics, compositions, and pharmaceutical compositions comprising same. Aspects and embodiments described herein may be used in medical treatment and disinfection of surfaces.