Invention Application
- Patent Title: HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES AND USE THEREOF
- Patent Title (中): 人巨细胞病毒中和抗体及其用途
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Application No.: PCT/IB2009/006641Application Date: 2009-07-15
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Publication No.: WO2010007533A2Publication Date: 2010-01-21
- Inventor: LANZAVECCHIA, Antonio , MACAGNO, Annalisa
- Applicant: INSTITUTE FOR RESEARCH IN BIOMEDICINE , LANZAVECCHIA, Antonio , MACAGNO, Annalisa
- Applicant Address: Via Vela 6 CH-6500 Bellinzona CH
- Assignee: INSTITUTE FOR RESEARCH IN BIOMEDICINE,LANZAVECCHIA, Antonio,MACAGNO, Annalisa
- Current Assignee: INSTITUTE FOR RESEARCH IN BIOMEDICINE,LANZAVECCHIA, Antonio,MACAGNO, Annalisa
- Current Assignee Address: Via Vela 6 CH-6500 Bellinzona CH
- Priority: US61/081,334 20080716
- Main IPC: C07K16/00
- IPC: C07K16/00
Abstract:
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
Information query
