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公开(公告)号：WO2016077789A8
公开(公告)日：2016-05-19
申请号：PCT/US2015/060733
申请日：2015-11-13
Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , CORTI, Davide , LANZAVECCHIA, Antonio , TREFRY, John
Inventor： CORTI, Davide , LANZAVECCHIA, Antonio , TREFRY, John , SULLIVAN, Nancy , MULANGU, Sabue , GRAHAM, Barncy , MUYEMBE-TAMFUN, Jean-jacques , LEDGERWOOD, Julie , STANLEY, Daphne
IPC: C07K16/10
Abstract: Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
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公开(公告)号：WO2016011035A2
公开(公告)日：2016-01-21
申请号：PCT/US2015/040385
申请日：2015-07-14
Applicant: MEDLMMUNE, LLC , CORTI, David , LANZAVECCHIA, Antonio
Inventor： CORTI, David , LANZAVECCHIA, Antonio , KALLEWAARD-LELAY, Nicole , ZHU, Qing , BENJAMIN, Ebony , WACHTER, Leslie , YUAN, Andy , McAULIFFE, Josephine, Mary
IPC: A61K39/42
CPC classification number: C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/11 , G01N2469/10
Abstract: The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
Abstract translation: 本发明涉及能够以两种系统发育不同的谱系与流感B病毒血凝素（HA）结合并中和乙型流感病毒的抗体及其抗原结合片段。 在一个实施方案中，抗体或抗原结合片段能够结合Yamagata和Victoria血统中的B型流感病毒血凝素并中和B型流感病毒。
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公开(公告)号：WO2016011035A8
公开(公告)日：2016-12-08
申请号：PCT/US2015040385
申请日：2015-07-14
Applicant: MEDIMMUNE LLC , CORTI DAVID , LANZAVECCHIA ANTONIO
Inventor： CORTI DAVID , LANZAVECCHIA ANTONIO , KALLEWAARD-LELAY NICOLE , ZHU QING , BENJAMIN EBONY , WACHTER LESLIE , YUAN ANDY , MCAULIFFE JOSEPHINE MARY
IPC: A61P31/16 , A61K39/145 , A61K39/395 , A61K39/42 , C07K16/10 , C12Q1/70 , G01N33/569
CPC classification number: C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/11 , G01N2469/10
Abstract: The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.
Abstract translation: 本发明涉及能够以两种系统发育不同谱系与流感B病毒血凝素（HA）结合并中和乙型流感病毒的抗体及其抗原结合片段。 在一个实施方案中，抗体或抗原结合片段能够结合Yamagata和Victoria血统中的B型流感病毒血凝素并中和B型流感病毒。
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公开(公告)号：WO2013011347A1
公开(公告)日：2013-01-24
申请号：PCT/IB2011/002329
申请日：2011-07-18
Inventor： LANZAVECCHIA, Antonio
CPC classification number: C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2760/16122 , G01N33/56983 , G01N2333/11 , G01N2469/10
Abstract: Antibodies, and antigen binding fragments thereof, that specifically bind to an epitope in the stem region of an influenza A hemagglutinin trimer and neutralize a group 1 subtype and a group 2 subtype of influenza A virus. Nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. In addition, the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
Abstract translation: 抗体及其抗原结合片段，其特异性结合甲型流感病毒血凝素三聚体的茎区域中的表位并中和甲型流感病毒的1亚型和2型亚型。 编码永生化B细胞和培养的单一浆细胞的核酸，其产生结合这些抗体和抗体片段的表位。 此外，在筛选方法以及甲型流感病毒感染的诊断，治疗和预防中使用抗体，抗体片段和表位。
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公开(公告)号：WO2010010466A2
公开(公告)日：2010-01-28
申请号：PCT/IB2009/006616
申请日：2009-07-27
Inventor： LANZAVECCHIA, Antonio
IPC: C07K16/00
CPC classification number: C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76
Abstract: The invention relates to antibodies, and antigen binding fragments thereof, that bind to hemagglutinin and neutralize a group 1 subtype and a group 2 subtype of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
Abstract translation: 本发明涉及结合血凝素并中和A型流感病毒亚型和亚型2型的抗体及其抗原结合片段。 本发明还涉及编码永生化B细胞和培养的单个浆细胞的核酸，其产生结合该抗体和抗体片段的表位。 此外，本发明涉及抗体，抗体片段和表位在筛选方法中的用途以及在甲型流感病毒感染的诊断，治疗和预防中的用途。
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Patent Agency Ranking
公开(公告)号：WO2008110937A3
公开(公告)日：2009-04-30
申请号：PCT/IB2008001527
申请日：2008-03-13
Applicant: HUMABS LLC , LANZAVECCHIA ANTONIO
Inventor： LANZAVECCHIA ANTONIO
CPC classification number: C07K16/1018 , C07K2317/21 , C07K2317/56 , C07K2317/565
Abstract: The inventor has provided human antibodies that can neutralize a H5N1 strain of influenza A virus. He has also provided antibodies that can neutralize a strain of influenza A virus in clade 2 of the H5 subtype, that can neutralize a H5N1 strain of influenza A virus and have a lambda light chain, and that are IgG antibodies (but not with a IgGI heavy chain) that can neutralize a H5N1 strain of influenza A virus.
Abstract translation: 本发明人提供可以中和A型流感病毒的H5N1毒株的人类抗体。 他还提供了可以中和H5亚型进化枝2中甲型流感病毒株的抗体，其可以中和A型流感病毒的H5N1毒株并具有λ轻链，并且是IgG抗体（但不与IgGI 重链），其可以中和A型流感病毒的H5N1毒株。
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公开(公告)号：WO2010007533A3
公开(公告)日：2010-08-12
申请号：PCT/IB2009006641
申请日：2009-07-15
Applicant: INST RESEARCH IN BIOMEDICINE , LANZAVECCHIA ANTONIO , MACAGNO ANNALISA
Inventor： LANZAVECCHIA ANTONIO , MACAGNO ANNALISA
IPC: C07K16/08
CPC classification number: C07K16/088 , A01D34/63 , A01D34/71 , A01D2101/00 , A61K38/00 , A61K39/00 , A61K39/42 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N2710/16122
Abstract: The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
Abstract translation: 本发明涉及在中和hCMV中具有高效力的中和抗体及其抗体片段，其中所述抗体和抗体片段对于一种或两种或更多种hCMV基因UL产品的组合是特异性的。 本发明还涉及产生和结合这些抗体和抗体片段的表位的永生化B细胞。 此外，本发明涉及抗体，抗体片段和表位在筛选方法以及疾病的诊断，预防和治疗中的用途。
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公开(公告)号：WO2010046775A2
公开(公告)日：2010-04-29
申请号：PCT/IB2009/007375
申请日：2009-10-22
Inventor： LANZAVECCHIA, Antonio , JARROSSAY, David
IPC: C07K16/00 , C12N5/0781 , C07K16/10 , C07K16/12
CPC classification number: C12N5/0635 , C07K16/00 , C07K16/1018 , C07K16/1282 , C07K2317/21 , C12N2502/1394
Abstract: The invention relates to methods of producing antibodies, including monoclonal antibodies, comprising culturing a limited number of plasma cells. It also relates to methods of identifying antibodies by performing assays on the antibodies produced by the cultured plasma cells to determine their function, binding specificity, epitope specificity, and/or their ability to neutralize a toxin or a pathogen. The invention also relates to antibodies and antibody fragments produced by the methods of the invention as well as methods of using the antibodies and antibody fragments.
Abstract translation: 本发明涉及生产包括单克隆抗体的抗体的方法，其包括培养有限数量的浆细胞。 本发明还涉及通过对由培养的浆细胞产生的抗体进行测定以确定其功能，结合特异性，表位特异性和/或其中和毒素或病原体的能力的方法来鉴定抗体的方法。 本发明还涉及通过本发明的方法产生的抗体和抗体片段以及使用该抗体和抗体片段的方法。
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公开(公告)号：WO2010043977A2
公开(公告)日：2010-04-22
申请号：PCT/IB2009/007372
申请日：2009-10-13
Inventor： LANZAVECCHIA, Antonio
CPC classification number: C07K16/1081 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , Y02A50/386
Abstract: The invention relates to antibodies and antigen binding fragments thereof and to cocktails of antibodies and antigen binding fragments that neutralize dengue virus infection without contributing to antibody-dependent enhancement of dengue virus infection. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antigen binding fragments. In addition, the invention relates to the use of the antibodies, antigen binding fragments, and epitopes in screening methods as well as in the diagnosis and therapy of dengue virus infection.
Abstract translation: 本发明涉及抗体及其抗原结合片段以及抗体和抗原结合片段的混合物，所述抗体和抗原结合片段中和登革病毒感染而无助于抗体依赖性登革热病毒感染增强。 本发明还涉及产生此类抗体和抗原结合片段的永生化B细胞以及结合此表位的永生化B细胞。 此外，本发明涉及抗体，抗原结合片段和表位在筛选方法以及登革病毒感染的诊断和治疗中的用途。
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公开(公告)号：WO2010010467A3
公开(公告)日：2010-01-28
申请号：PCT/IB2009/006623
申请日：2009-07-27
Inventor： LANZAVECCHIA, Antonio
IPC: C07K16/00 , C12N5/0781 , C07K16/10 , C07K16/12
Abstract: The invention relates to antibodies and antigen binding fragments thereof, that bind to hemagglutinin and neutralize infection of at least two different group 1 subtypes or at least two different group 2 subtypes of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
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