Systems include one or more medicinal storage containers. For example, an integrally thermally sealed medicinal storage container may include one or more segments of at least one ultra efficient insulation material, the one or more segments having one or more surface regions, the one or more segments principally defining at least one storage region, one or more regions of substantially thermally sealed connections between at least one of the one or more surface regions of the one or more segments wherein the one or more regions of substantially thermally sealed connections and the one or more segments form at least one integrally thermally sealed medicinal storage region, one or more thermal variant units, and at least one selectively-operable thermal conduction unit.