Invention Application
- Patent Title: HDL PARTICLES FOR DELIVERY OF NUCLEIC ACIDS
- Patent Title (中): 用于输送核酸的HDL颗粒
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Application No.: PCT/US2009/064834Application Date: 2009-11-17
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Publication No.: WO2010057203A2Publication Date: 2010-05-20
- Inventor: SOOD, Anil, K. , LACKO, Andras, G. , LOPEZ-BERESTEIN, Gabriel , MANGALA, Lingegowda, S. , MCCONATHY, Walter, J. , PROKAI, Laszlo , NAIR, Maya, P.
- Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , SOOD, Anil, K. , LACKO, Andras, G. , LOPEZ-BERESTEIN, Gabriel , MANGALA, Lingegowda, S. , MCCONATHY, Walter, J. , PROKAI, Laszlo , NAIR, Maya, P. , UNT HEALTH SCIENCE CENTER AT FORT WORTH , TEXAS TECH UNIVERSITY SYSTEM
- Applicant Address: 201 W. 7th St. Austin, TX 78701 US
- Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM,SOOD, Anil, K.,LACKO, Andras, G.,LOPEZ-BERESTEIN, Gabriel,MANGALA, Lingegowda, S.,MCCONATHY, Walter, J.,PROKAI, Laszlo,NAIR, Maya, P.,UNT HEALTH SCIENCE CENTER AT FORT WORTH,TEXAS TECH UNIVERSITY SYSTEM
- Current Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM,SOOD, Anil, K.,LACKO, Andras, G.,LOPEZ-BERESTEIN, Gabriel,MANGALA, Lingegowda, S.,MCCONATHY, Walter, J.,PROKAI, Laszlo,NAIR, Maya, P.,UNT HEALTH SCIENCE CENTER AT FORT WORTH,TEXAS TECH UNIVERSITY SYSTEM
- Current Assignee Address: 201 W. 7th St. Austin, TX 78701 US
- Agency: DE LA PAZ, Monica A.
- Priority: US61/115,387 20081117
- Main IPC: C07K14/775
- IPC: C07K14/775 ; C07H21/00 ; A61P35/00
Abstract:
Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.
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