公开(公告)号：WO2009099959A3

公开(公告)日：2009-08-13

申请号：PCT/US2009/032689

申请日：2009-01-30

Applicant: THE BOARD OF REGENTS OF TEH UNIVERSITY OF TEXAS SYSTEM ,  ELLIS, Lee, M. ,  GRAY, Michael, J. ,  SOOD, Anil, K. ,  LOPEZ-BERESTEIN, Gabriel

Inventor： ELLIS, Lee, M. ,  GRAY, Michael, J. ,  SOOD, Anil, K. ,  LOPEZ-BERESTEIN, Gabriel

IPC: A61K48/00 ,  A61P35/00 ,  A61K31/7105 ,  A61K9/127

Abstract: Disclosed are compositions that include a nucleic acid component that include a nucleic acid that inhibits the expression of a gene that encodes a neuropilin, and a lipid component that includes one or more neutral phospholipids. Also disclosed are compositions that include a nucleic acid component that includes a nucleic acid that inhibits the expression of a gene that encodes neuropilin-2 (NRP-2). Also disclosed are methods of treating a subject with cancer that involve administering to the subject a pharmaceutically effective amount of a composition of the present invention.

公开(公告)号：WO2009099959A2

公开(公告)日：2009-08-13

申请号：PCT/US2009032689

申请日：2009-01-30

Applicant: TEH UNIVERSITY OF TEXAS SYSTEM ,  ELLIS LEE M ,  GRAY MICHAEL J ,  SOOD ANIL K ,  LOPEZ-BERESTEIN GABRIEL

Inventor： ELLIS LEE M ,  GRAY MICHAEL J ,  SOOD ANIL K ,  LOPEZ-BERESTEIN GABRIEL

IPC: A61K48/00 ,  A61K9/127 ,  A61P35/00

CPC classification number: C12N15/1138 ,  A61K48/00 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/51

Abstract: Disclosed are compositions that include a nucleic acid component that include a nucleic acid that inhibits the expression of a gene that encodes a neuropilin, and a lipid component that includes one or more neutral phospholipids. Also disclosed are compositions that include a nucleic acid component that includes a nucleic acid that inhibits the expression of a gene that encodes neuropilin-2 (NRP-2). Also disclosed are methods of treating a subject with cancer that involve administering to the subject a pharmaceutically effective amount of a composition of the present invention.

Abstract translation: 公开了包含核酸组分的组合物，其包括抑制编码神经纤维蛋白的基因的表达的核酸和包含一种或多种中性磷脂的脂质组分。 还公开了包含核酸组分的组合物，其包含抑制编码神经纤维蛋白-2（NRP-2）的基因的表达的核酸。 还公开了治疗患有癌症的受试者的方法，其涉及向受试者施用药学有效量的本发明的组合物。

公开(公告)号：WO2009002719A1

公开(公告)日：2008-12-31

申请号：PCT/US2008/066753

申请日：2008-06-12

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  LANDEN, Charles, N. ,  KAMAT, Aparna, A. ,  SOOD, Anil, K. ,  LOPEZ-BERESTEIN, Gabriel

Inventor： LANDEN, Charles, N. ,  KAMAT, Aparna, A. ,  SOOD, Anil, K. ,  LOPEZ-BERESTEIN, Gabriel

IPC: A01N43/04

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: The present invention relates to the fields of molecular biology and drug delivery. Disclosed are compositions that include a nucleic acid targeted to a STAT gene and a neutral lipid. Also disclosed are methods of treating a human subject with a disease associated with increased expression of a STAT involving administering to the subject a pharmaceutically effective amount of a composition that includes a nucleic acid targeted to a STAT gene and a neutral lipid. Specific embodiments pertain to a method of treating cancer comprising administering to a subject a pharmaceutically effective amount of a composition that includes an siRNA targeted to STAT3 and a neutral lipid.

Abstract translation: 本发明涉及分子生物学和药物递送领域。 公开了包含靶向STAT基因和中性脂质的核酸的组合物。 还公开了治疗患有与STAT的表达增加相关的疾病的人类受试者的方法，其涉及向受试者施用药学有效量的包含靶向STAT基因和中性脂质的核酸的组合物。 具体实施方案涉及治疗癌症的方法，包括向受试者施用药学有效量的包含针对STAT3的siRNA和中性脂质的组合物。

公开(公告)号：WO2008109432A3

公开(公告)日：2008-09-12

申请号：PCT/US2008/055486

申请日：2008-02-29

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  MERRITT, William, K. ,  SOOD, Anil, K. ,  BAR-ELI, Menashe ,  LOPEZ-BERESTEIN, Gabriel

Inventor： MERRITT, William, K. ,  SOOD, Anil, K. ,  BAR-ELI, Menashe ,  LOPEZ-BERESTEIN, Gabriel

IPC: C12Q1/68 ,  C12P19/34 ,  C12N15/63 ,  C12N15/88 ,  A61K38/00 ,  C07K1/00 ,  A01N43/04 ,  C07H21/02 ,  C07H21/04

Abstract: The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides compositions that include an siRNA targeted to an interleukin and a neutral lipid, and methods of treating a human subject with cancer involving administering to the subject a pharmarceutically effective amount of an interleukin-8 antagonist or a composition as set forth herein.

公开(公告)号：WO2010057203A3

公开(公告)日：2010-09-16

申请号：PCT/US2009064834

申请日：2009-11-17

Applicant: UNIV TEXAS ,  SOOD ANIL K ,  LACKO ANDRAS G ,  LOPEZ-BERESTEIN GABRIEL ,  MANGALA LINGEGOWDA S ,  MCCONATHY WALTER J ,  PROKAI LASZLO ,  NAIR MAYA P ,  UNT HEALTH SCIENCE CT AT FORT ,  UNIV TEXAS TECH SYSTEM

Inventor： SOOD ANIL K ,  LACKO ANDRAS G ,  LOPEZ-BERESTEIN GABRIEL ,  MANGALA LINGEGOWDA S ,  MCCONATHY WALTER J ,  PROKAI LASZLO ,  NAIR MAYA P

IPC: C07K14/775 ,  A61P35/00 ,  C07H21/00

CPC classification number: C07K14/775 ,  A61K47/6911 ,  A61K48/0041 ,  C12N15/111 ,  C12N15/88 ,  C12N2320/32

Abstract: Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.

Abstract translation: 公开了高密度脂蛋白 - 核酸颗粒，其中颗粒包括（a）载脂蛋白; （b）包含治疗性核酸片段的核酸组分; 和（c）包含带正电荷的区域的多肽，其中多肽的带正电荷的区域与核酸组分结合。 还公开了药物组合物，其包含a）载脂蛋白; （b）包含治疗性核酸片段的核酸组分; 和（c）包含带正电荷区域的多肽。 还涉及本发明的颗粒和药物组合物的方法以及试剂盒。

公开(公告)号：WO2009070609A3

公开(公告)日：2010-09-10

申请号：PCT/US2008084742

申请日：2008-11-25

Applicant: UNIV TEXAS ,  SOOD ANIL ,  LOPEZ-BERESTEIN GABRIEL ,  ARMAIZ-PENA GUILLERMO

Inventor： SOOD ANIL ,  LOPEZ-BERESTEIN GABRIEL ,  ARMAIZ-PENA GUILLERMO

IPC: A61K9/127 ,  A61K31/138 ,  A61P35/00 ,  C12N15/113

CPC classification number: A61K9/127 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2320/32

Abstract: Disclosed are compositions that include a nucleic acid component that include a nucleic acid that inhibits the expression of a gene that encodes interleukin-6 (IL-6), and a lipid component that includes one or more phospholipids. Also disclosed are methods of treating a subject with cancer that exhibits stress-related growth involve administering to the subject a pharmaceutically effective amount of a composition that includes a nucleic acid component that includes a nucleic acid that inhibits the expression of a gene that encodes IL- 6, and a lipid component comprising one or more phospholipids.

Abstract translation: 公开了包含核酸组分的组合物，其包含抑制编码白细胞介素-6（IL-6）的基因表达的核酸和包含一种或多种磷脂的脂质组分。 还公开了治疗患有应激相关生长的癌症的受试者的方法，其涉及向受试者施用药学有效量的组合物，所述组合物包括核酸组分，其包含抑制编码IL- 6和包含一种或多种磷脂的脂质组分。

公开(公告)号：WO2009059201A2

公开(公告)日：2009-05-07

申请号：PCT/US2008082079

申请日：2008-10-31

Applicant: UNIV TEXAS ,  ELLIS LEE M ,  GRAY MICHAEL J ,  SOOD ANIL ,  LOPEZ-BERESTEIN GABRIEL

Inventor： ELLIS LEE M ,  GRAY MICHAEL J ,  SOOD ANIL ,  LOPEZ-BERESTEIN GABRIEL

IPC: A61K48/00 ,  A61P35/00

CPC classification number: C12N15/113 ,  C12N2310/14

Abstract: Disclosed are compositions that include a nucleic acid component that include a nucleic acid that inhibits the expression of a gene that encodes an inhibitor of DNA binding protein (Id), and a lipid component that includes one or more phospholipids. Also disclosed are methods of treating a subject with cancer that involve administering to the subject a pharmaceutically effective amount of a composition that includes a nucleic acid component that includes a nucleic acid that inhibits the expression of a gene that encodes Id2, and a lipid component comprising one or more phospholipids.

Abstract translation: 公开了包含核酸组分的组合物，所述核酸组分包含抑制编码DNA结合蛋白（Id）抑制剂的基因的表达的核酸和包含一种或多种磷脂的脂质组分。 还公开了治疗患有癌症的受试者的方法，所述方法涉及向所述受试者施用药学有效量的组合物，所述组合物包含核酸组分和脂质组分，所述组合物包含抑制编码Id2的基因的表达的核酸组分， 一种或多种磷脂。

公开(公告)号：WO2007149062A2

公开(公告)日：2007-12-27

申请号：PCT/US2006/009044

申请日：2006-03-14

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  LIN, Jacki ,  ARLINGHAUS, Ralph, B. ,  SUN, Tong ,  JI, Lin, X. ,  OZPOLAT, Bulent ,  LOPEZ-BERESTEIN, Gabriel ,  ROTH, Jack, A.

Inventor： LIN, Jacki ,  ARLINGHAUS, Ralph, B. ,  SUN, Tong ,  JI, Lin, X. ,  OZPOLAT, Bulent ,  LOPEZ-BERESTEIN, Gabriel ,  ROTH, Jack, A.

CPC classification number: A61K47/48892 ,  A61K9/127 ,  A61K9/1272 ,  A61K38/10 ,  A61K38/162 ,  A61K38/17 ,  A61K47/6911 ,  A61K47/6929 ,  B82Y5/00 ,  B82Y10/00 ,  C07K14/4703

Abstract: A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.

Abstract translation: 一种纳米颗粒 - 多肽复合物，其包含与纳米颗粒结合的生物活性多肽，其中所述生物活性多肽通过添加促进蛋白质的细胞摄取的化学部分而被修饰。 多肽可以是蛋白质或肽。 在一些实施方案中，蛋白质或肽的氨基酸序列衍生自肿瘤抑制基因产物的氨基酸序列。

公开(公告)号：WO2002041871A3

公开(公告)日：2002-05-30

申请号：PCT/US2001/043292

申请日：2001-11-20

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA ,  LOPEZ-BERESTEIN, Gabriel ,  REMERS, William, A. ,  HERSH, Evan, M.

Inventor： LOPEZ-BERESTEIN, Gabriel ,  REMERS, William, A. ,  HERSH, Evan, M.

IPC: A61K31/396

Abstract: Disclosed are novel compositions comprising a lipid and imexon or a derivative thereof. Also disclosed are liposomal compositions comprising imexon or derivative thereof. Methods for administrating pharmaceutically acceptable compositions comprising a lipid and imexon or a derivative thereof for the treatment of diseases, such as cancer, are also disclosed herein.

公开(公告)号：WO2013063492A1

公开(公告)日：2013-05-02

申请号：PCT/US2012/062256

申请日：2012-10-26

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  OZPOLAT, Bulent ,  LOPEZ-BERESTEIN, Gabriel ,  DALBY, Kevin N. ,  JOSE, Jiney

Inventor： OZPOLAT, Bulent ,  LOPEZ-BERESTEIN, Gabriel ,  DALBY, Kevin N. ,  JOSE, Jiney

IPC: C07D471/04 ,  C07D209/10 ,  C07D403/12 ,  A61K31/437 ,  A61P35/00

CPC classification number: A61K31/437 ,  A61K31/404 ,  A61K45/06 ,  C07D209/14 ,  C07D209/18 ,  C07D209/20 ,  C07D403/12 ,  C07D471/04 ,  C07D471/14

Abstract: Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression.

Abstract translation: 本文提供的方法和组合物尤其用于治疗疾病，包括过度增生性疾病，偏头痛和抑郁症。