Invention Application
WO2011062964A1 COMPOUNDS AND METHODS FOR ALTERING LIFESPAN OF EUKARYOTIC ORGANISMS
审中-公开
用于改变真菌生物活性成分的化合物和方法
- Patent Title: COMPOUNDS AND METHODS FOR ALTERING LIFESPAN OF EUKARYOTIC ORGANISMS
- Patent Title (中): 用于改变真菌生物活性成分的化合物和方法
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Application No.: PCT/US2010/056990Application Date: 2010-11-17
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Publication No.: WO2011062964A1Publication Date: 2011-05-26
- Inventor: GOLDFARB, David, S. , MADDRY, Joseph, A. , RASMUSSEN, Lynn , WHITE, Ellie, Lucile , WENNERBERG, Krister
- Applicant: UNIVERSITY OF ROCHESTER , SOUTHERN RESEARCH INSTITUTE , GOLDFARB, David, S. , MADDRY, Joseph, A. , RASMUSSEN, Lynn , WHITE, Ellie, Lucile , WENNERBERG, Krister
- Applicant Address: Office Of Technology Transfer 611 Hylan Building Rochester, NY 14627-0142 US
- Assignee: UNIVERSITY OF ROCHESTER,SOUTHERN RESEARCH INSTITUTE,GOLDFARB, David, S.,MADDRY, Joseph, A.,RASMUSSEN, Lynn,WHITE, Ellie, Lucile,WENNERBERG, Krister
- Current Assignee: UNIVERSITY OF ROCHESTER,SOUTHERN RESEARCH INSTITUTE,GOLDFARB, David, S.,MADDRY, Joseph, A.,RASMUSSEN, Lynn,WHITE, Ellie, Lucile,WENNERBERG, Krister
- Current Assignee Address: Office Of Technology Transfer 611 Hylan Building Rochester, NY 14627-0142 US
- Agency: WATT, Rachel, S. et al.
- Priority: US61/261,851 20091117
- Main IPC: A01N35/00
- IPC: A01N35/00 ; A61K31/13
Abstract:
Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5 -butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.
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