Invention Application
WO2011089396A2 PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE.
审中-公开
PYRUVAMIDE化合物作为DITE MITE 1 PEPTIDASE ALLERGEN及其使用的抑制剂。
- Patent Title: PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE.
- Patent Title (中): PYRUVAMIDE化合物作为DITE MITE 1 PEPTIDASE ALLERGEN及其使用的抑制剂。
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Application No.: PCT/GB2011/000079Application Date: 2011-01-21
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Publication No.: WO2011089396A2Publication Date: 2011-07-28
- Inventor: ROBINSON, Clive , ZHANG, Jihui , GARROD, David, Ronald , PERRIOR, Trevor, Robert , NEWTON, Gary, Karl , JENKINS, Kerry , BEEVERS, Rebekah, Elisabeth , KIMBERLEY, Meriel, Ruth , STEWART, Mark, Richard
- Applicant: ST GEORGE'S HOSPITAL MEDICAL SCHOOL , THE UNIVERSITY OF MANCHESTER , ROBINSON, Clive , ZHANG, Jihui , GARROD, David, Ronald , PERRIOR, Trevor, Robert , NEWTON, Gary, Karl , JENKINS, Kerry , BEEVERS, Rebekah, Elisabeth , KIMBERLEY, Meriel, Ruth , STEWART, Mark, Richard
- Applicant Address: Cranmer Terrace Tooting London SW17 0RE GB
- Assignee: ST GEORGE'S HOSPITAL MEDICAL SCHOOL,THE UNIVERSITY OF MANCHESTER,ROBINSON, Clive,ZHANG, Jihui,GARROD, David, Ronald,PERRIOR, Trevor, Robert,NEWTON, Gary, Karl,JENKINS, Kerry,BEEVERS, Rebekah, Elisabeth,KIMBERLEY, Meriel, Ruth,STEWART, Mark, Richard
- Current Assignee: ST GEORGE'S HOSPITAL MEDICAL SCHOOL,THE UNIVERSITY OF MANCHESTER,ROBINSON, Clive,ZHANG, Jihui,GARROD, David, Ronald,PERRIOR, Trevor, Robert,NEWTON, Gary, Karl,JENKINS, Kerry,BEEVERS, Rebekah, Elisabeth,KIMBERLEY, Meriel, Ruth,STEWART, Mark, Richard
- Current Assignee Address: Cranmer Terrace Tooting London SW17 0RE GB
- Agency: WYTENBURG, Wilhelmus, J et al.
- Priority: GB1001070.0 20100122
- Main IPC: C07K5/06
- IPC: C07K5/06 ; C07K5/08 ; A61P37/08 ; A61P37/06
Abstract:
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as "PVA compounds"), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.
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