公开(公告)号：WO2022184790A1

公开(公告)日：2022-09-09

申请号：PCT/EP2022/055313

申请日：2022-03-02

申请人： THE UNIVERSITY OF MANCHESTER

发明人： ROBERTS, Aled ,  SCRUTTON, Nigel ,  MALONE, Kirk ,  COSGROVE, Sebastian ,  NI CHEALLAIGH, Aisling ,  PAYNE, Karl

IPC分类号： C12N11/12 ,  C08B1/00 ,  D21C5/00 ,  C12N9/10 ,  C12N9/20

摘要： The present invention relates to a macromolecule scaffold comprising wood-derived cellulose. The cellulose comprises a plurality of elongate lumen and the scaffold is substantially de-lignified. The present invention also provides a method of producing a macromolecule scaffold. The method comprises treating wood with a solution comprising sodium hydroxide and sodium sulphite and a solution comprising hydrogen peroxide.

公开(公告)号：WO2022175666A1

公开(公告)日：2022-08-25

申请号：PCT/GB2022/050427

申请日：2022-02-17

申请人： THE UNIVERSITY OF MANCHESTER

发明人： ALLAN, Stuart McRae ,  SOUTH, Kieron

IPC分类号： C12N9/64 ,  A61K38/48 ,  A61P7/02 ,  A61P29/00

摘要： The disclosure provides improved ADAMTS13 variants with amino acid substitutions in the linker 3 region. The disclosure also provides methods for producing and using the variants.

公开(公告)号：WO2021250413A1

公开(公告)日：2021-12-16

申请号：PCT/GB2021/051445

申请日：2021-06-10

申请人： THE UNIVERSITY OF MANCHESTER

发明人： GREBENNIKOVA, Tatiana ,  SHARRAD, Clint Alan ,  JONES, Abbie Nadia

IPC分类号： G21F9/00 ,  G21F9/30 ,  G21F9/002

摘要： The present invention relates to methods of decontaminating irradiated nuclear graphite. The method comprises immersing the irradiated nuclear graphite in a molten salt electrolyte, and subjecting the irradiated nuclear graphite to an electrochemical treatment.

公开(公告)号：WO2021240147A1

公开(公告)日：2021-12-02

申请号：PCT/GB2021/051272

申请日：2021-05-26

申请人： THE UNIVERSITY OF MANCHESTER

发明人： KOCABAS, Coskun ,  BAKAN, Gokhan ,  ERGOKTAS, Muhammed Said

IPC分类号： G02B5/00 ,  G02B5/20 ,  G02B5/22 ,  G02F1/15

摘要： This invention relates to devices that can controllably vary the properties of graphene with respect to different wavelengths of electromagnetic radiation and particularly its optical properties. The electronically variable optical surfaces of the invention comprise graphene layers with intercalated metal (e.g. lithium) ions. The cell comprises an Li-NMC anode as ion source, an ionic liquid electrolyte, and an multilayer graphene cathode.

公开(公告)号：WO2021224430A1

公开(公告)日：2021-11-11

申请号：PCT/EP2021/062077

申请日：2021-05-06

申请人： THE UNIVERSITY OF MANCHESTER

发明人： BISHOP, Paul ,  CLARK, Simon ,  UNWIN, Richard

IPC分类号： G01N33/68

摘要： Methods for detecting and determining the level of complement proteins are disclosed, in particular using mass spectrometry. Also disclosed are methods of identifying subjects having or at risk of developing a complement-related disorder, and methods of treating the same.

公开(公告)号：WO2021156637A1

公开(公告)日：2021-08-12

申请号：PCT/GB2021/050269

申请日：2021-02-05

申请人： THE UNIVERSITY OF MANCHESTER

发明人： BARRAN, Perdita ,  SARKAR, Depanjan ,  TRIVEDI, Drupad ,  SINCLAIR, Eleanor ,  SILVERDALE, Monty ,  MILNE, Joy

IPC分类号： G01N33/50 ,  G01N33/92

摘要： The present invention relates to methods for detecting the presence or absence of Parkinson's disease (PD).

公开(公告)号：WO2021014154A1

公开(公告)日：2021-01-28

申请号：PCT/GB2020/051752

申请日：2020-07-22

申请人： THE UNIVERSITY OF MANCHESTER

发明人： KIMBER, Susan ,  LEWIS, Philip

IPC分类号： G01N33/50

摘要： The present invention relates to methods for assessing the pluripotent state of a stem cell culture by determining the presence of marker proteins, related kits and uses.

公开(公告)号：WO2021013452A1

公开(公告)日：2021-01-28

申请号：PCT/EP2020/067448

申请日：2020-06-23

申请人： THE UNIVERSITY OF MANCHESTER ,  SEOUL NATIONAL UNIVERSITY HOSPITAL

发明人： DAY, Anthony ,  MILNER, Caroline ,  OH, Joo Youn

IPC分类号： A61K38/17 ,  A61K9/00 ,  A61K31/4725 ,  A61K31/573 ,  A61K38/13 ,  A61P27/02 ,  A61P27/04

摘要： The present invention relates to the treatment of dry eye disease and particularly, although not exclusively, to the treatment of dry eye disease with a LINK_TSG6 polypeptide.

公开(公告)号：WO2020204814A1

公开(公告)日：2020-10-08

申请号：PCT/SG2020/050154

申请日：2020-03-23

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  THE UNIVERSITY OF MANCHESTER

发明人： CHOO, Sern Farh Matthew ,  NGUYEN-KHUONG, Terry ,  PALLISTER, Edward George ,  NG, Say Kong ,  FLITSCH, Sabine Lahja

IPC分类号： C12P21/00 ,  C07K14/81 ,  A61K38/55 ,  A61P11/00 ,  A61P1/16

摘要： The invention relates to a method of increasing the number of α2,3,-α2,6-disialylgalactose N -glycans on a glycoprotein by incubating an α2,3-sialylated glycoprotein with an α2,6-sialyltransferase and a sialic acid source. Also provided is a recombinant glycoprotein comprising at least one α2,3,-α2,6-disialylgalactose N -glycan. In a particular embodiment, the recombinant glycoprotein is alpha-1 antitrypsin (AAT).

公开(公告)号：WO2020152442A1

公开(公告)日：2020-07-30

申请号：PCT/GB2020/050109

申请日：2020-01-20

申请人： THE UNIVERSITY OF MANCHESTER

发明人： RAVEENDRAN NAIR, Rahul ,  SREEPAL, Vishnu

IPC分类号： B01D67/00 ,  B01D69/12 ,  B01D69/14 ,  B01D71/02

摘要： This invention relates to membranes comprising 2D phyllosilicate coatings, e.g. 2D vermiculite coatings. The 2D phyllosilicateflakes are associated with cations. The invention also relates to methods of using said membranes, e.g. in filtration methods.