Invention Application
WO2012072715A2 USE OF PROKARYOTIC SPHINGOSINE-1-PHOSPHATE LYASES AND OF SPHINGOSINE-1-PHOSPHATE LYASES LACKING A TRANSMEMBRANE DOMAIN FOR TREATING HYPERPROLIFERATIVE AND OTHER DISEASES
审中-公开
用于治疗超增生性和其他疾病的原核神经鞘氨醇-1-磷酸酯酶抑制剂和缺乏跨膜结构域的天冬碱-1-磷酸酯酶的应用
- Patent Title: USE OF PROKARYOTIC SPHINGOSINE-1-PHOSPHATE LYASES AND OF SPHINGOSINE-1-PHOSPHATE LYASES LACKING A TRANSMEMBRANE DOMAIN FOR TREATING HYPERPROLIFERATIVE AND OTHER DISEASES
- Patent Title (中): 用于治疗超增生性和其他疾病的原核神经鞘氨醇-1-磷酸酯酶抑制剂和缺乏跨膜结构域的天冬碱-1-磷酸酯酶的应用
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Application No.: PCT/EP2011071446Application Date: 2011-11-30
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Publication No.: WO2012072715A2Publication Date: 2012-06-07
- Inventor: ZANGEMEISTER-WITTKE UWE , HUWILER ANDREA , GRUETTER MARKUS G , BOURQUIN FLORENCE
- Applicant: UNIV ZUERICH , UNIV BERN , ZANGEMEISTER-WITTKE UWE , HUWILER ANDREA , GRUETTER MARKUS G , BOURQUIN FLORENCE
- Assignee: UNIV ZUERICH,UNIV BERN,ZANGEMEISTER-WITTKE UWE,HUWILER ANDREA,GRUETTER MARKUS G,BOURQUIN FLORENCE
- Current Assignee: UNIV ZUERICH,UNIV BERN,ZANGEMEISTER-WITTKE UWE,HUWILER ANDREA,GRUETTER MARKUS G,BOURQUIN FLORENCE
- Priority: EP10193347 2010-12-01
Abstract:
The present invention relates to the use of prokaryotic sphingosine-1 -phosphate lyases (S1PL) and S1PLs that lack a transmembrane domain or of a nucleic acid encoding such an S1PL in the prevention or treatment of a disease condition associated with elevated levels of sphingosine-1 -phosphate (S1P), and for which S1P elevation is directly or indirectly causative. In addition, the invention relates to a new product in the form of S1PL lacking the N-terminal loop domain.
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